Abstract Information in proteins flows from sequence to structure to function, with each step
causally driven by the preceding one. Protein design is founded on inverting this process …

Biomolecules exhibit dynamic behavior that single-state models of their structures cannot
fully capture. We review some recent advances for investigating multiple conformations of …

In the folded state, biomolecules exchange between multiple conformational states crucial
for their function. However, most structural models derived from experiments and …

Protein tyrosine phosphatase 1B (PTP1B) plays important roles in cellular homeostasis and
is a highly validated therapeutic target for multiple human ailments, including diabetes …

Abstract Protein Data Bank (PDB) files list the relative spatial location of atoms in a protein
structure as the final output of the process of fitting and refining to experimentally determined …

Proteins are well knownshapeshifters' which change conformation to function. In
crystallography, multiple conformational states are often present within the crystal and the …

Serial crystallography, born from groundbreaking experiments at the Linac Coherent Light
Source in 2009, has evolved into a pivotal technique in structural biology. Initially pioneered …

Protein tyrosine phosphatase 1B (PTP1B) plays important roles in cellular homeostasis and
is a highly validated therapeutic target for multiple human ailments including diabetes …

By converting a disordered polymer into a globular structure, protein folding reduces many
conformational degrees of freedom, resulting in a significant conformational entropy penalty …