Spinal cord injury (SCI) is a major cause of disability, and at present, there is no universally
accepted treatment. The functional decline following SCI is contributed to both direct …

Research on the foreign body response (FBR) to biomaterial implants has been focused on
the roles that the innate immune system has on mediating tolerance or rejection of implants …

Primary damage caused by injury to the CNS is often followed by delayed degeneration of
initially spared neurons. Studies in our laboratory have shown that active or passive …

Neurotrophins (NTs) promote neuronal survival and maintenance during development and
after injury. However, their role in the communication between the nervous system and the …

Neurons have been neglected as cells with a major immune-regulatory function because
they do not express major histocompatibility complex class II. Our data show that neurons …

We recently reported that the posttraumatic spread of degeneration in the damaged optic
nerve can be attenuated by the adoptive transfer of autoimmune T cells specific to myelin …

Our group recently demonstrated that autoimmune T cells directed against central nervous
system-associated myelin antigens protect neurons from secondary degeneration. We …

Multiple sclerosis is a chronic demyelinating inflammatory disease of the central nervous
system (CNS). As the tissue macrophage of the CNS, microglia have the potential to …

Although neurodegenerative diseases such as Alzheimer's disease are not classically
considered mediated by inflammation or the immune system, in some instances the immune …

Inflammation has been widely perceived as participating in the etiology of acute and chronic
neurodegenerative conditions. Accordingly, in the context of traumatic injuries or chronic …