Interactions of commensal and pathogenic microorganisms with the intestinal mucosal barrier

EC Martens, M Neumann, MS Desai - Nature Reviews Microbiology, 2018 - nature.com
The intestinal mucosal barrier is composed of epithelial cells that are protected by an
overlying host-secreted mucous layer and functions as the first line of defence against …

Inflammation and inflammatory cytokine contribute to the initiation and development of ulcerative colitis and its associated cancer

D Yao, M Dong, C Dai, S Wu - Inflammatory bowel diseases, 2019 - academic.oup.com
Dysregulated inflammatory responses play a pivotal role in the initiation, development, and
progression of tumors, as demonstrated by the association between ulcerative colitis and the …

TLR4 regulates RORγt+ regulatory T-cell responses and susceptibility to colon inflammation through interaction with Akkermansia muciniphila

Y Liu, M Yang, L Tang, F Wang, S Huang, S Liu, Y Lei… - Microbiome, 2022 - Springer
Background Well-balanced interactions between gut microbiota and the immune system are
essential to prevent chronic intestinal inflammation, as observed in inflammatory bowel …

[HTML][HTML] Experimental models of inflammatory bowel diseases

P Kiesler, IJ Fuss, W Strober - Cellular and molecular gastroenterology and …, 2015 - Elsevier
The understanding of the intestinal inflammation occurring in the inflammatory bowel
diseases (IBD) has been immeasurably advanced by the development of the now numerous …

Ceria–Zirconia nanoparticles as an enhanced multi‐antioxidant for sepsis treatment

M Soh, DW Kang, HG Jeong, D Kim, DY Kim… - Angewandte …, 2017 - Wiley Online Library
The two oxidation states of ceria nanoparticles, Ce3+ and Ce4+, play a pivotal role in
scavenging reactive oxygen species (ROS). In particular, Ce3+ is largely responsible for …

Dextran sodium sulphate colitis mouse model: traps and tricks

M Perše, A Cerar - BioMed Research International, 2012 - Wiley Online Library
Inflammatory bowel disease (IBD) is a complex multifactorial disease of unknown etiology.
Thus, dozens of different animal models of IBD have been developed in past decades …

Toll-like receptor signalling in the intestinal epithelium: how bacterial recognition shapes intestinal function

MT Abreu - Nature reviews immunology, 2010 - nature.com
A single layer of epithelial cells lines the small and large intestines and functions as a barrier
between commensal bacteria and the rest of the body. Ligation of Toll-like receptors (TLRs) …

The gut flora as a forgotten organ

AM O'Hara, F Shanahan - EMBO reports, 2006 - embopress.org
The intestinal microflora is a positive health asset that crucially influences the normal
structural and functional development of the mucosal immune system. Mucosal immune …

[HTML][HTML] Role of the gut microbiota in inflammatory bowel disease pathogenesis: what have we learnt in the past 10 years?

GL Hold, M Smith, C Grange, ER Watt… - World journal of …, 2014 - ncbi.nlm.nih.gov
Our understanding of the microbial involvement in inflammatory bowel disease (IBD)
pathogenesis has increased exponentially over the past decade. The development of newer …

Microbiology, genomics, and clinical significance of the Pseudomonas fluorescens species complex, an unappreciated colonizer of humans

BS Scales, RP Dickson, JJ LiPuma… - Clinical microbiology …, 2014 - Am Soc Microbiol
Pseudomonas fluorescens is not generally considered a bacterial pathogen in humans;
however, multiple culture-based and culture-independent studies have identified it at low …