Malaria is a tropical disease, leading to around half a million deaths annually. Antimalarials
such as quinolines are crucial to fight against malaria, but malaria control is extremely …

Malaria is a life threatening disease caused by microscopic parasites called Plasmodium
that are transmitted to human beings by mosquitoes. Single celled Eukaryotic plasmodium …

Abstract Human African trypanosomiasis (HAT), Chagas disease and leishmaniasis, which
are caused by the trypanosomatids Trypanosoma brucei, Trypanosoma cruzi and …

The problems associated with the drugs currently used to treat leishmaniasis, including
resistance, toxicity, and the high cost of some formulations, call for the urgent identification of …

Almost 110 years after the first studies by Dr. Carlos Chagas describing an infectious
disease that was named for him, Chagas disease remains a neglected illness and a death …

Background By 2016, signs of emergence of Plasmodium falciparum resistance to
artemisinin and partner drugs were detected in the Greater Mekong Subregion. Recently …

Multi-target drug development has become an attractive strategy in the discovery of drugs to
treat of Alzheimer's disease (AzD). In this study, for the first time, a rule-based machine …

Leishmaniasis and Chagas disease are endemic pathologies in tropical countries. These
cause high morbidity and a public health problem. Current chemotherapies are based on …

Aza-Michael adducts are obtained in excellent yields by the conjugate addition of
nucleophilic reagents with α, β-unsaturated substrates such as methyl methacrylate (MMA) …

Widespread outbreak of numerous infectious diseases and metabolic disorders across the
globe has created awareness among the chemists for novel design and synthesis of natural …