Consensus guidelines for the use and interpretation of angiogenesis assays
The formation of new blood vessels, or angiogenesis, is a complex process that plays
important roles in growth and development, tissue and organ regeneration, as well as …
important roles in growth and development, tissue and organ regeneration, as well as …
Current status of angiogenic cell therapy and related strategies applied in critical limb ischemia
L Beltrán-Camacho, M Rojas-Torres… - International Journal of …, 2021 - mdpi.com
Critical limb ischemia (CLI) constitutes the most severe form of peripheral arterial disease
(PAD), it is characterized by progressive blockade of arterial vessels, commonly correlated …
(PAD), it is characterized by progressive blockade of arterial vessels, commonly correlated …
Inhibition of 14q32 MicroRNAs miR-329, miR-487b, miR-494, and miR-495 increases neovascularization and blood flow recovery after ischemia
SMJ Welten, AJNM Bastiaansen, RCM de Jong… - Circulation …, 2014 - Am Heart Assoc
Rationale: Effective neovascularization is crucial for recovery after cardiovascular events.
Objective: Because microRNAs regulate expression of up to several hundred target genes …
Objective: Because microRNAs regulate expression of up to several hundred target genes …
MicroRNA-411 and Its 5′-IsomiR have distinct targets and functions and are differentially regulated in the vasculature under ischemia
RVCT van der Kwast, T Woudenberg, PHA Quax… - Molecular Therapy, 2020 - cell.com
MicroRNAs are posttranscriptional regulators of gene expression. As microRNAs can target
many genes simultaneously, microRNAs can regulate complex multifactorial processes …
many genes simultaneously, microRNAs can regulate complex multifactorial processes …
Variations in surgical procedures for inducing hind limb ischemia in mice and the impact of these variations on neovascularization assessment
Z Aref, MR de Vries, PHA Quax - International journal of molecular …, 2019 - mdpi.com
Mouse hind limb ischemia is the most common used preclinical model for peripheral arterial
disease and critical limb ischemia. This model is used to investigate the mechanisms of …
disease and critical limb ischemia. This model is used to investigate the mechanisms of …
Adenosine-to-inosine editing of vasoactive microRNAs alters their targetome and function in ischemia
RVCT van der Kwast, L Parma, ML van der Bent… - … Therapy-Nucleic Acids, 2020 - cell.com
Adenosine-to-inosine (A-to-I) editing in the seed sequence of microRNAs can shift the
microRNAs' targetomes and thus their function. Using public RNA-sequencing data, we …
microRNAs' targetomes and thus their function. Using public RNA-sequencing data, we …
Characterization of the arterial anatomy of the murine hindlimb: functional role in the design and understanding of ischemia models
T Kochi, Y Imai, A Takeda, Y Watanabe, S Mori… - PloS one, 2013 - journals.plos.org
Rationale Appropriate ischemia models are required for successful studies of therapeutic
angiogenesis. While collateral routes are known to be present within the innate vasculature …
angiogenesis. While collateral routes are known to be present within the innate vasculature …
[HTML][HTML] Toward a mouse model of hind limb ischemia to test therapeutic angiogenesis
RA Brenes, CC Jadlowiec, M Bear, P Hashim… - Journal of vascular …, 2012 - Elsevier
INTRODUCTION: Several clinical trials are currently evaluating stem cell therapy for patients
with critical limb ischemia that have no other surgical or endovascular options for …
with critical limb ischemia that have no other surgical or endovascular options for …
[HTML][HTML] Targeted delivery of nanomedicines for promoting vascular regeneration in ischemic diseases
Ischemic diseases, the leading cause of disability and death, are caused by the restriction or
blockage of blood flow in specific tissues, including ischemic cardiac, ischemic …
blockage of blood flow in specific tissues, including ischemic cardiac, ischemic …
Release of basic fibroblast growth factor from acoustically-responsive scaffolds promotes therapeutic angiogenesis in the hind limb ischemia model
H Jin, C Quesada, M Aliabouzar, OD Kripfgans… - Journal of Controlled …, 2021 - Elsevier
Pro-angiogenic growth factors have been studied as potential therapeutics for
cardiovascular diseases like critical limb ischemia (CLI). However, the translation of these …
cardiovascular diseases like critical limb ischemia (CLI). However, the translation of these …