The formation of new blood vessels, or angiogenesis, is a complex process that plays
important roles in growth and development, tissue and organ regeneration, as well as …

Critical limb ischemia (CLI) constitutes the most severe form of peripheral arterial disease
(PAD), it is characterized by progressive blockade of arterial vessels, commonly correlated …

Rationale: Effective neovascularization is crucial for recovery after cardiovascular events.
Objective: Because microRNAs regulate expression of up to several hundred target genes …

MicroRNAs are posttranscriptional regulators of gene expression. As microRNAs can target
many genes simultaneously, microRNAs can regulate complex multifactorial processes …

Mouse hind limb ischemia is the most common used preclinical model for peripheral arterial
disease and critical limb ischemia. This model is used to investigate the mechanisms of …

Adenosine-to-inosine (A-to-I) editing in the seed sequence of microRNAs can shift the
microRNAs' targetomes and thus their function. Using public RNA-sequencing data, we …

Rationale Appropriate ischemia models are required for successful studies of therapeutic
angiogenesis. While collateral routes are known to be present within the innate vasculature …

INTRODUCTION: Several clinical trials are currently evaluating stem cell therapy for patients
with critical limb ischemia that have no other surgical or endovascular options for …

Ischemic diseases, the leading cause of disability and death, are caused by the restriction or
blockage of blood flow in specific tissues, including ischemic cardiac, ischemic …

Pro-angiogenic growth factors have been studied as potential therapeutics for
cardiovascular diseases like critical limb ischemia (CLI). However, the translation of these …