Long non-coding RNAs: definitions, functions, challenges and recommendations
Genes specifying long non-coding RNAs (lncRNAs) occupy a large fraction of the genomes
of complex organisms. The term 'lncRNAs' encompasses RNA polymerase I (Pol I), Pol II …
of complex organisms. The term 'lncRNAs' encompasses RNA polymerase I (Pol I), Pol II …
Mechanism of epithelial‐mesenchymal transition in cancer and its regulation by natural compounds
HL Ang, CD Mohan, MK Shanmugam… - Medicinal research …, 2023 - Wiley Online Library
Epithelial‐mesenchymal transition (EMT) is a complex process with a primordial role in
cellular transformation whereby an epithelial cell transforms and acquires a mesenchymal …
cellular transformation whereby an epithelial cell transforms and acquires a mesenchymal …
LNCcation: lncRNA localization and function
MC Bridges, AC Daulagala, A Kourtidis - Journal of Cell Biology, 2021 - rupress.org
Subcellular localization of RNAs has gained attention in recent years as a prevalent
phenomenon that influences numerous cellular processes. This is also evident for the large …
phenomenon that influences numerous cellular processes. This is also evident for the large …
Overview of histone modification
Epigenetics is the epi-information beyond the DNA sequence that can be inherited from
parents to offspring. From years of studies, people have found that histone modifications …
parents to offspring. From years of studies, people have found that histone modifications …
Regulation of gene expression by cis-acting long non-coding RNAs
N Gil, I Ulitsky - Nature Reviews Genetics, 2020 - nature.com
Long non-coding RNAs (lncRNAs) are diverse transcription products emanating from
thousands of loci in mammalian genomes. Cis-acting lncRNAs, which constitute a …
thousands of loci in mammalian genomes. Cis-acting lncRNAs, which constitute a …
Long non-coding RNA in the pathogenesis of cancers
Y Chi, D Wang, J Wang, W Yu, J Yang - Cells, 2019 - mdpi.com
The incidence and mortality rate of cancer has been quickly increasing in the past decades.
At present, cancer has become the leading cause of death worldwide. Most of the cancers …
At present, cancer has become the leading cause of death worldwide. Most of the cancers …
New insights into the interplay between long non‐coding RNAs and RNA‐binding proteins in cancer
ZT Yao, YM Yang, MM Sun, Y He, L Liao… - Cancer …, 2022 - Wiley Online Library
With the development of proteomics and epigenetics, a large number of RNA‐binding
proteins (RBPs) have been discovered in recent years, and the interaction between long …
proteins (RBPs) have been discovered in recent years, and the interaction between long …
Long non-coding RNAs in the regulation of gene expression: physiology and disease
The identification of RNAs that are not translated into proteins was an important
breakthrough, defining the diversity of molecules involved in eukaryotic regulation of gene …
breakthrough, defining the diversity of molecules involved in eukaryotic regulation of gene …
The functions and unique features of long intergenic non-coding RNA
JD Ransohoff, Y Wei, PA Khavari - Nature reviews Molecular cell …, 2018 - nature.com
Long intergenic non-coding RNA (lincRNA) genes have diverse features that distinguish
them from mRNA-encoding genes and exercise functions such as remodelling chromatin …
them from mRNA-encoding genes and exercise functions such as remodelling chromatin …
lncRNA THAP7-AS1, transcriptionally activated by SP1 and post-transcriptionally stabilized by METTL3-mediated m6A modification, exerts oncogenic properties by …
HT Liu, YX Zou, W Zhu, G Zhang, RR Ma… - Cell Death & …, 2022 - nature.com
Long noncoding RNAs (lncRNAs) are dysregulated in different cancer types, and thus have
emerged as important regulators of the initiation and progression of human cancers …
emerged as important regulators of the initiation and progression of human cancers …