Obesity and cancer pathogenesis

NA Berger - Annals of the New York Academy of Sciences, 2014 - Wiley Online Library
Overweight and obesity have reached pandemic levels on a worldwide basis and are
associated with increased risk and worse prognosis for many but not all malignancies …

[HTML][HTML] Obesity and cancer: mechanistic insights from transdisciplinary studies

EH Allott, SD Hursting - Endocrine-related cancer, 2015 - erc.bioscientifica.com
Obesity is associated with a range of health outcomes that are of clinical and public health
significance, including cancer. Herein, we summarize epidemiologic and preclinical …

[HTML][HTML] Cholesterol and saturated fatty acids synergistically promote the malignant progression of prostate cancer

X Wang, B Sun, L Wei, X Jian, K Shan, Q He, F Huang… - Neoplasia, 2022 - Elsevier
The excessive accumulation of saturated fatty acids and cholesterol have been linked to
prostate cancer (Pca). Here, we found that lipoproteins, apolipoproteins, triglycerides and …

[HTML][HTML] Research evidence on high-fat diet-induced prostate cancer development and progression

S Narita, T Nara, H Sato, A Koizumi, M Huang… - Journal of clinical …, 2019 - mdpi.com
Although recent evidence has suggested that a high-fat diet (HFD) plays an important role in
prostate carcinogenesis, the underlying mechanisms have largely remained unknown. This …

Proinflammatory cytokines in prostate cancer development and progression promoted by high‐fat diet

H Xu, M Hu, P Bai, W Zhu, S Liu, J Hou… - BioMed research …, 2015 - Wiley Online Library
Background. We aimed to examine whether proinflammatory cytokines participated in
prostate cancer (PCa) development and progression promoted by high‐fat diet (HFD) …

[HTML][HTML] A high-fat diet containing lard accelerates prostate cancer progression and reduces survival rate in mice: possible contribution of adipose tissue-derived …

HJ Cho, GT Kwon, H Park, H Song, KW Lee, JI Kim… - Nutrients, 2015 - mdpi.com
To examine the effects of high-fat diet (HFD) containing lard on prostate cancer development
and progression and its underlying mechanisms, transgenic adenocarcinoma mouse …

[HTML][HTML] High-fat diet‑induced adipokine and cytokine alterations promote the progression of prostate cancer in vivo and in vitro

MB Hu, H Xu, WH Zhu, PD Bai, JM Hu… - Oncology …, 2018 - spandidos-publications.com
Abstract High-fat diet (HFD)‑induced obesity is associated with more aggressive and lethal
prostate cancer (PCa) in males, although the exact underlying mechanisms remain unclear …

[HTML][HTML] Linking obesogenic dysregulation to prostate cancer progression

RA Taylor, J Lo, N Ascui, MJ Watt - Endocrine Connections, 2015 - ec.bioscientifica.com
The global epidemic of obesity is closely linked to the development of serious co-
morbidities, including many forms of cancer. Epidemiological evidence consistently shows …

[HTML][HTML] Obesity does not promote tumorigenesis of localized patient-derived prostate cancer xenografts

JCY Lo, AK Clark, N Ascui, M Frydenberg… - Oncotarget, 2016 - ncbi.nlm.nih.gov
There are established epidemiological links between obesity and the severity of prostate
cancer. We directly tested this relationship by assessing tumorigenicity of patient-derived …

[HTML][HTML] Maternal high-fat diet promotes the development and progression of prostate cancer in transgenic adenocarcinoma mouse prostate offspring

T Yang, X Wu, J Hu, M Hu, H Xu, H Jiang… - Cellular Physiology and …, 2018 - karger.com
Background/Aims: We aim to investigate the impact of maternal high fat diet (HFD) on the
development and progression of prostate cancer (PCa) in transgenic adenocarcinoma …