Chronic hypoxic exposure induces changes in the structure of pulmonary arteries, as well as
in the biochemical and functional phenotypes of each of the vascular cell types, from the …

Hypoxic pulmonary hypertension (PH) comprises a heterogeneous group of diseases
sharing the common feature of chronic hypoxia-induced pulmonary vascular remodeling …

This review analyses the mechanisms by which lung fluid balance is strictly controlled in the
air-blood barrier (ABB). Relatively large trans-endothelial and trans-epithelial Starling …

The aim of this study is to evaluate molecules involved in oxidative stress (OS),
inflammation, angiogenesis, and apoptosis, and discern which of these are more likely to be …

We discuss the translocation of inhaled asbestos fibers based on pulmonary and pleuro-
pulmonary interstitial fluid dynamics. Fibers can pass the alveolar barrier and reach the lung …

The pathophysiology of high-altitude pulmonary edema is currently attributed to exacerbated
heterogeneous hypoxic pulmonary vasoconstriction. However, although other cellular …

Pleural and interstitial lung fluid volumes are strictly controlled and maintained at the
minimum thanks to the ability of lymphatics to match the increase in filtration rate. In the …

When considering which components of the cell are the most critical to function and
physiology, we naturally focus on the nucleus, the mitochondria that regulate energy and …

Pulmonary hypoxia is a common complication of chronic lung diseases leading to the
development of pulmonary hypertension. The underlying sustained increase in vascular …

The extracellular matrix is composed of a three-dimensional fiber mesh filled with different
macromolecules such as: collagen (mainly type I and III), elastin, glycosaminoglycans, and …