Parkinson's disease (PD) is a neurodegenerative disorder characterized by selective loss of
dopaminergic neurons in the substantia nigra pars compacta (SNpc) region of the midbrain …

G protein-gated inwardly rectifying K+ (GIRK/Kir3) channels exert a critical inhibitory
influence on neurons. Neuronal GIRK channels mediate the G protein-dependent …

Chronic cocaine exposure induces enduring neuroadaptations that facilitate motivated drug
taking. Hyperpolarization-activated cyclic nucleotide-gated (HCN) channels are known to …

G protein-gated inwardly rectifying potassium (GIRK) channels are essential regulators of
cell excitability in the brain. While they are implicated in a variety of neurological diseases in …

We integrated genomic and bioinformatic analyses, using data from the largest genome-
wide association study of cocaine dependence (CD; n= 6546; 82.37% with CD; 57.39 …

Background and Purpose Drugs of abuse, including alcohol, increase dopamine in the
mesocorticolimbic system via actions on dopamine neurons in the ventral tegmental area …

Excessive alcohol intake, eg, binge drinking, is a serious and mounting public health
problem in the United States and throughout the world. Hence the need for novel insights …

Rationale Transgenic mouse lines expressing Cre-recombinase under the regulation of
either dopamine transporter (DAT) or tyrosine hydroxylase (TH) promoters are commonly …

Abstract Dopamine D2 autoreceptors (D 2 ARs), located in somatodendritic and axon
terminal compartments of dopamine (DA) neurons, function to provide a negative feedback …

Nucleus incertus (NI) is a brainstem structure involved in the control of arousal, stress
responses and locomotor activity. It was reported recently that NI neurons express the …