Cancer remains the second leading cause of mortality worldwide. In the course of this
multistage and multifactorial disease, a set of alterations takes place, with genetic and …

Adipose tissue is the largest endocrine organ and an accepted contributor to overall energy
homeostasis. There is strong evidence linking increased adiposity to the development of 13 …

Existing explanations of obesity-associated cancer emphasise direct mutagenic effects of
dietary components or hormonal imbalance. Some of these hypotheses are reviewed briefly …

Abstract Caveolin-1 (CAV1) is an oncogenic membrane protein associated with endocytosis,
extracellular matrix organisation, cholesterol distribution, cell migration and signaling …

Obesity is associated with an increased risk of estrogen receptor-positive breast cancer in
postmenopausal women and a worse prognosis for all major breast cancer subtypes …

The adipocyte-released hormone-like cytokine/adipokine leptin behaves differently in
obesity compared to its functions in the normal healthy state. In obese individuals, elevated …

Cancer cells exhibit unique metabolic response and adaptation to the fluctuating
microenvironment, yet molecular and biochemical events imprinting this phenomenon are …

Abstract Since the mid-1950's, melanoma incidence has been rising steadily in
industrialized Caucasian populations, thereby pointing to the pivotal involvement of …

Background Cutaneous melanoma is one of the most aggressive and lethal skin cancers. It
is greatly important to identify prognostic biomarkers to guide the clinical management …

Background One of the factors that affect the progression of melanoma is the tumor
microenvironment, which consists of cellular elements, extracellular matrix, acidification, and …