Dominant optic atrophy: Culprit mitochondria in the optic nerve

G Lenaers, A Neutzner, Y Le Dantec, C Jüschke… - Progress in Retinal and …, 2021 - Elsevier
Dominant optic atrophy (DOA) is an inherited mitochondrial disease leading to specific
degeneration of retinal ganglion cells (RGCs), thus compromising transmission of visual …

AMPK is mitochondrial medicine for neuromuscular disorders

AI Mikhail, SY Ng, SR Mattina, V Ljubicic - Trends in Molecular Medicine, 2023 - cell.com
Duchenne muscular dystrophy (DMD), myotonic dystrophy type 1 (DM1), and spinal
muscular atrophy (SMA) are the most prevalent neuromuscular disorders (NMDs) in children …

Remodeling of mitochondrial plasticity: the key switch from NAFLD/NASH to HCC

M Longo, E Paolini, M Meroni… - International journal of …, 2021 - mdpi.com
Hepatocellular carcinoma (HCC) is the most common primary malignancy of the liver and
the third-leading cause of cancer-related mortality. Currently, the global burden of …

CRISPR-Cas9 correction of OPA1 c. 1334G> A: p. R445H restores mitochondrial homeostasis in dominant optic atrophy patient-derived iPSCs

PE Sladen, PRL Perdigão, G Salsbury… - … Therapy-Nucleic Acids, 2021 - cell.com
Autosomal dominant optic atrophy (DOA) is the most common inherited optic neuropathy in
the United Kingdom. DOA has an insidious onset in early childhood, typically presenting …

The role of mitochondrial dynamics in mtDNA maintenance

R Sabouny, TE Shutt - Journal of cell science, 2021 - journals.biologists.com
The dynamic nature of mitochondria, which can fuse, divide and move throughout the cell,
allows these critical organelles to adapt their function in response to cellular demands, and …

A single dose of exercise stimulates skeletal muscle mitochondrial plasticity in myotonic dystrophy type 1

AI Mikhail, A Manta, SY Ng, AK Osborne… - Acta …, 2023 - Wiley Online Library
Aim Myotonic dystrophy type 1 (DM1) is the second most common muscular dystrophy after
Duchenne and is the most prevalent muscular dystrophy in adults. DM1 patients that …

Modelling autosomal dominant optic atrophy associated with OPA1 variants in iPSC-derived retinal ganglion cells

PE Sladen, K Jovanovic, R Guarascio… - Human Molecular …, 2022 - academic.oup.com
Autosomal dominant optic atrophy (DOA) is the most common inherited optic neuropathy,
characterized by the preferential loss of retinal ganglion cells (RGCs), resulting in optic …

[PDF][PDF] RETRACTED: Opa1 Reduces Hypoxia-Induced Cardiomyocyte Death by Improving Mitochondrial Quality Control

T Xin, W Lv, D Liu, Y Jing, F Hu - Frontiers in Cell and Developmental …, 2020 - frontiersin.org
Mitochondrial dysfunction contributes to cardiovascular disorders, especially post-infarction
cardiac injury, through incompletely characterized mechanisms. Among the latter, increasing …

Activated Immune System Determines In Vivo Anti‐Tumor Effect of Phototherapy by Inhibiting Cancer‐Associated Fibroblasts

M Ding, H Chen, CF Guimarães… - Advanced Functional …, 2024 - Wiley Online Library
Immune activation has been widely recognized to promote anti‐tumor effects in vivo.
However, in previous anti‐tumor studies of combined photo/immunotherapy, the tumor …

Bringing together but staying apart: decisive differences in animal and fungal mitochondrial inner membrane fusion

H Hashimi, O Gahura, T Pánek - Biological Reviews, 2024 - Wiley Online Library
Mitochondria are dynamic and plastic, undergoing continuous fission and fusion and
rearrangement of their bioenergetic sub‐compartments called cristae. These fascinating …