The association of histones with specific chaperone complexes is important for their folding,
oligomerization, post-translational modification, nuclear import, stability, assembly and …

The packaging of DNA into strings of nucleosomes is one of the features that allows
eukaryotic cells to tightly regulate gene expression. The ordered disassembly of …

Identification of host genes essential for severe acute respiratory syndrome coronavirus 2
(SARS-CoV-2) infection may reveal novel therapeutic targets and inform our understanding …

Despite substantial progress in lung cancer immunotherapy, the overall response rate in
patients with KRAS-mutant lung adenocarcinoma (LUAD) remains low. Combining standard …

Altered DNA methylation and associated destabilization of genome integrity and function is
a hallmark of cancer. Replicative senescence is a tumour suppressor process that imposes …

Eukaryotic gene regulation involves a balance between packaging of the genome into
nucleosomes and enabling access to regulatory proteins and RNA polymerase …

The functional organization of eukaryotic DNA into chromatin uses histones as components
of its building block, the nucleosome. Histone chaperones, which are proteins that escort …

Summary Polycomb repressive complex 2 (PRC2) regulates gene expression during
lineage specification through trimethylation of lysine 27 on histone H3 (H3K27me3). In …

The histone variants H3. 3 and H2A. Z have recently emerged as two of the most important
features in transcriptional regulation, the molecular mechanism of which still remains poorly …

Hsp70s comprise a deeply conserved chaperone family that has a central role in
maintaining protein homeostasis. In humans, Hsp70 client specificity is provided by 49 …