Sphingolipids, sphingolipid metabolizing enzymes, and their receptors network are being
recognized as part of the signaling mechanisms, which govern breast cancer cell growth …

Tissue damage, irrespective from the underlying etiology, destroys tissue structure and,
eventually, function. In attempt to achieve a morpho-functional recover of the damaged …

Cardiac ischemia/reperfusion, loss of blood flow and its subsequent restoration, causes
damage to the heart. Oxidative stress from ischemia/reperfusion leads to dysfunction and …

Rationale: Vascular remodeling in pulmonary arterial hypertension (PAH) results from
smooth muscle cell hypertrophy and proliferation of vascular cells. Loss of BMPR-II (bone …

Aging is by far the dominant risk factor for the development of cardiovascular diseases,
whose prevalence dramatically increases with increasing age reaching epidemic …

Abstract Sphingosine-1-phosphate (S1P), a bioactive lysophospholipid, is generated and
released at sites of tissue injury in the heart and can act on S1P 1, S1P 2, and S1P 3 …

Epithelial‐mesenchymal transition (EMT) is a critical process implicated in the initial stage of
cancer metastasis, which is the major cause of tumor recurrence and mortality. Although key …

Balanced sphingolipid signaling is important for the maintenance of homeostasis.
Sphingolipids were demonstrated to function as structural components, second messengers …

Icariin, the main active flavonoid glucoside isolated from Herba epimedii, has been
demonstrated to be a potential alternative therapy to prevent postmenopausal osteoporosis …

Known as a variety of sphingolipid metabolites capable of performing various biological
activities, sphingosine 1‐phosphate (S1P) is commonly found in platelets, red blood cells …