Pathogenetic mechanisms and treatment targets in cerebral malaria
Malaria, the most prevalent mosquito-borne infectious disease worldwide, has accompanied
humanity for millennia and remains an important public health issue despite advances in its …
humanity for millennia and remains an important public health issue despite advances in its …
[HTML][HTML] Peroxisome proliferator-activated receptor-targeted therapies: Challenges upon infectious diseases
IS Kim, P Silwal, EK Jo - Cells, 2023 - mdpi.com
Peroxisome proliferator-activated receptors (PPARs) α, β, and γ are nuclear receptors that
orchestrate the transcriptional regulation of genes involved in a variety of biological …
orchestrate the transcriptional regulation of genes involved in a variety of biological …
Plasmodium falciparum and TNF-α differentially regulate inflammatory and barrier integrity pathways in human brain endothelial cells
M Zuniga, C Gomes, Z Chen, C Martinez, JC Devlin… - MBio, 2022 - Am Soc Microbiol
Cerebral malaria is a severe complication of Plasmodium falciparum infection characterized
by the loss of blood-brain barrier (BBB) integrity, which is associated with brain swelling and …
by the loss of blood-brain barrier (BBB) integrity, which is associated with brain swelling and …
[HTML][HTML] Dimethyl fumarate triggers the antioxidant defense system in human retinal endothelial cells through Nrf2 activation
F Manai, M Amadio - Antioxidants, 2022 - mdpi.com
Dimethyl fumarate (DMF) is a well-known activator of Nrf2 (NF-E2-related factor 2), used in
the treatment of psoriasis and multiple sclerosis. The mechanism of action consists in the …
the treatment of psoriasis and multiple sclerosis. The mechanism of action consists in the …
Cerebral malaria – modelling interactions at the blood–brain barrier in vitro
Y Adams, AR Jensen - Disease Models & Mechanisms, 2022 - journals.biologists.com
The blood–brain barrier (BBB) is a continuous endothelial barrier that is supported by
pericytes and astrocytes and regulates the passage of solutes between the bloodstream and …
pericytes and astrocytes and regulates the passage of solutes between the bloodstream and …
[HTML][HTML] History of tuberculosis disease is associated with genetic regulatory variation in Peruvians
VE Nieto-Caballero, JF Reijneveld, A Ruvalcaba… - PLoS …, 2024 - journals.plos.org
A quarter of humanity is estimated to have been exposed to Mycobacterium tuberculosis
(Mtb) with a 5–10% risk of developing tuberculosis (TB) disease. Variability in responses to …
(Mtb) with a 5–10% risk of developing tuberculosis (TB) disease. Variability in responses to …
[HTML][HTML] Diffraction contrast in cryo-scanning transmission electron tomography reveals the boundary of hemozoin crystals in situ
Malaria is a potentially fatal infectious disease caused by the obligate intracellular parasite
Plasmodium falciparum. The parasite infects human red blood cells (RBC) and derives …
Plasmodium falciparum. The parasite infects human red blood cells (RBC) and derives …
[HTML][HTML] Biochemical characteristics of patients with imported malaria
D Bi, J Lin, X Luo, L Lin, X Tang, X Luo, Y Lu… - Frontiers in cellular …, 2022 - frontiersin.org
Objectives This study aimed to investigate the clinical and biochemical profiles of patients
with imported malaria infection between 1 January 2011 and 30 April 2022 and admitted to …
with imported malaria infection between 1 January 2011 and 30 April 2022 and admitted to …
[HTML][HTML] The role of Nrf2 signaling in parasitic diseases and its therapeutic potential
M Vatankhah, R Panahizadeh, A Safari, A Ziyabakhsh… - Heliyon, 2024 - cell.com
In response to invading parasites, one of the principal arms of innate immunity is oxidative
stress, caused by reactive oxygen species (ROS). However, oxidative stresses play dual …
stress, caused by reactive oxygen species (ROS). However, oxidative stresses play dual …
[HTML][HTML] A human pluripotent stem cell-derived in vitro model of the blood–brain barrier in cerebral malaria
A Gopinadhan, JM Hughes, AL Conroy… - Fluids and Barriers of …, 2024 - Springer
Background Blood–brain barrier (BBB) disruption is a central feature of cerebral malaria
(CM), a severe complication of Plasmodium falciparum (Pf) infections. In CM, sequestration …
(CM), a severe complication of Plasmodium falciparum (Pf) infections. In CM, sequestration …