Malaria, the most prevalent mosquito-borne infectious disease worldwide, has accompanied
humanity for millennia and remains an important public health issue despite advances in its …

Peroxisome proliferator-activated receptors (PPARs) α, β, and γ are nuclear receptors that
orchestrate the transcriptional regulation of genes involved in a variety of biological …

Cerebral malaria is a severe complication of Plasmodium falciparum infection characterized
by the loss of blood-brain barrier (BBB) integrity, which is associated with brain swelling and …

Dimethyl fumarate (DMF) is a well-known activator of Nrf2 (NF-E2-related factor 2), used in
the treatment of psoriasis and multiple sclerosis. The mechanism of action consists in the …

The blood–brain barrier (BBB) is a continuous endothelial barrier that is supported by
pericytes and astrocytes and regulates the passage of solutes between the bloodstream and …

A quarter of humanity is estimated to have been exposed to Mycobacterium tuberculosis
(Mtb) with a 5–10% risk of developing tuberculosis (TB) disease. Variability in responses to …

Malaria is a potentially fatal infectious disease caused by the obligate intracellular parasite
Plasmodium falciparum. The parasite infects human red blood cells (RBC) and derives …

Objectives This study aimed to investigate the clinical and biochemical profiles of patients
with imported malaria infection between 1 January 2011 and 30 April 2022 and admitted to …

In response to invading parasites, one of the principal arms of innate immunity is oxidative
stress, caused by reactive oxygen species (ROS). However, oxidative stresses play dual …

Background Blood–brain barrier (BBB) disruption is a central feature of cerebral malaria
(CM), a severe complication of Plasmodium falciparum (Pf) infections. In CM, sequestration …