Microbial fibrinolytic enzymes as anti-thrombotics: production, characterisation and prodigious biopharmaceutical applications

C Sharma, A Osmolovskiy, R Singh - Pharmaceutics, 2021 - mdpi.com
Cardiac disorders such as acute myocardial infarction, embolism and stroke are primarily
attributed to excessive fibrin accumulation in the blood vessels, usually consequential in …

Marine microbial alkaline protease: An efficient and essential tool for various industrial applications

N Barzkar - International Journal of Biological Macromolecules, 2020 - Elsevier
With the modern world focusing on environmental friendly products, more and more
chemical processes are being replaced by enzymatic methods. Alkaline proteases (APases) …

Potential application spectrum of microbial proteases for clean and green industrial production

S Singh, BK Bajaj - Energy, Ecology and Environment, 2017 - Springer
Enzymes are the cornerstones of metabolism and constitute the fundamental basis for
existence of life. However, recently enzymes are being implicated in diverse industrial …

Characterization of AprE176, a fibrinolytic enzyme from Bacillus subtilis HK176

SJ Jeong, K Heo, JY Park, KW Lee… - … of Microbiology and …, 2015 - koreascience.kr
Bacillus subtilis HK176 with high fibrinolytic activity was isolated from cheonggukjang, a
Korean fermented soyfood. A gene, aprE176, encoding the major fibrinolytic enzyme was …

Fibrin and fibrinolytic enzyme cascade in thrombosis: unravelling the role

R Singh, P Gautam, C Sharma, A Osmolovskiy - Life, 2023 - mdpi.com
Blood clot formation in blood vessels (thrombosis) is a major cause of life-threatening
cardiovascular diseases. These clots are formed by αA-, βB-, and ϒ-peptide chains of …

Purification, biochemical, and structural characterization of a novel fibrinolytic enzyme from Mucor subtilissimus UCP 1262

TP Nascimento, AE Sales, TS Porto… - Bioprocess and …, 2017 - Springer
Fibrinolytic proteases are enzymes that degrade fibrin. They provide a promising alternative
to existing drugs for thrombolytic therapy. A protease isolated from the filamentous fungus …

Enterohemorrhagic Escherichia coli OmpT regulates outer membrane vesicle biogenesis

V Premjani, D Tilley, S Gruenheid… - FEMS Microbiology …, 2014 - academic.oup.com
Enterohemorrhagic Escherichia coli (EHEC) infection from food or water often results in
severe diarrheal disease and is a leading cause of death globally. Outer membrane vesicles …

Purification and biochemical characterization of a novel fibrinolytic enzyme from Streptomyces sp. P3

G Cheng, L He, Z Sun, Z Cui, Y Du… - Journal of Microbiology …, 2015 - koreascience.kr
A novel proteolytic enzyme with fibrinolytic activity, FSP3, was purified from the recently
isolated Streptomyces sp. P3, which is a novel bacterial strain isolated from soil. FSP3 was …

Proteases, a powerful biochemical tool in the service of medicine, clinical and pharmaceutical

GA Jamal, E Jahangirian, MR Hamblin… - Preparative …, 2024 - Taylor & Francis
Proteases, enzymes that hydrolyze peptide bonds, have various applications in medicine,
clinical applications, and pharmaceutical development. They are used in cancer treatment …

A novel Ca2+-dependent alkaline serine-protease (Bvsp) from Bacillus sp. with high fibrinolytic activity

Q Cheng, F Xu, N Hu, X Liu, Z Liu - Journal of Molecular Catalysis B …, 2015 - Elsevier
Based on a genomic library constructed, a novel alkaline serine protease gene (Bvsp)(963
bp) was cloned from a marine bacterium Bacillus vallismortis, encoding 320 amino acid …