Reactive oxygen species (ROS) as pleiotropic physiological signalling agents

H Sies, DP Jones - Nature reviews Molecular cell biology, 2020 - nature.com
Abstract 'Reactive oxygen species'(ROS) is an umbrella term for an array of derivatives of
molecular oxygen that occur as a normal attribute of aerobic life. Elevated formation of the …

Nanozymes: classification, catalytic mechanisms, activity regulation, and applications

Y Huang, J Ren, X Qu - Chemical reviews, 2019 - ACS Publications
Because of the high catalytic activities and substrate specificity, natural enzymes have been
widely used in industrial, medical, and biological fields, etc. Although promising, they often …

Chemical basis of reactive oxygen species reactivity and involvement in neurodegenerative diseases

F Collin - International journal of molecular sciences, 2019 - mdpi.com
Increasing numbers of individuals suffer from neurodegenerative diseases, which are
characterized by progressive loss of neurons. Oxidative stress, in particular, the …

Selenium utilization by GPX4 is required to prevent hydroperoxide-induced ferroptosis

I Ingold, C Berndt, S Schmitt, S Doll, G Poschmann… - Cell, 2018 - cell.com
Selenoproteins are rare proteins among all kingdoms of life containing the 21 st amino acid,
selenocysteine. Selenocysteine resembles cysteine, differing only by the substitution of …

Metal–organic‐framework‐engineered enzyme‐mimetic catalysts

L Ma, F Jiang, X Fan, L Wang, C He, M Zhou… - Advanced …, 2020 - Wiley Online Library
Nanomaterial‐based enzyme‐mimetic catalysts (Enz‐Cats) have received considerable
attention because of their optimized and enhanced catalytic performances and selectivities …

Nanozyme-involved biomimetic cascade catalysis for biomedical applications

X Cai, L Jiao, H Yan, Y Wu, W Gu, D Du, Y Lin, C Zhu - Materials Today, 2021 - Elsevier
Enzyme cascade reactions in biological systems can effectively improve the catalytic
performances owing to their high local concentration, efficient mass transfer and reduced …

Biochemistry of peroxynitrite and protein tyrosine nitration

G Ferrer-Sueta, N Campolo, M Trujillo… - Chemical …, 2018 - ACS Publications
Peroxynitrite is a short-lived and reactive biological oxidant formed from the diffusion-
controlled reaction of the free radicals superoxide (O2•–) and nitric oxide (• NO). In this …

Enzyme mimics for engineered biomimetic cascade nanoreactors: mechanism, applications, and prospects

X Zhang, G Li, G Chen, D Wu, Y Wu… - Advanced Functional …, 2021 - Wiley Online Library
Multiple enzyme‐driven biological catalytic cascades occur in living organisms, guiding
highly efficient and selective transformations of substrates. Inspired by the merits of these …

Achieving the balance between ROS and antioxidants: when to use the synthetic antioxidants

B Poljsak, D Šuput, I Milisav - Oxidative medicine and cellular …, 2013 - Wiley Online Library
Free radical damage is linked to formation of many degenerative diseases, including cancer,
cardiovascular disease, cataracts, and aging. Excessive reactive oxygen species (ROS) …

Oxidative stress in rheumatoid arthritis: What the future might hold regarding novel biomarkers and add‐on therapies

LJS Fonseca, V Nunes-Souza… - Oxidative medicine …, 2019 - Wiley Online Library
Numerous rheumatologic autoimmune diseases, among which rheumatoid arthritis, are
chronic inflammatory diseases capable of inducing multiple cumulative articular and extra …