Bacterial infections have attracted the attention of researchers in recent decades, especially
due to the special problems they have faced, such as their increasing diversity and …

Tumor suppressor p53 can transcriptionally activate downstream genes in response to
stress, and then regulate the cell cycle, DNA repair, metabolism, angiogenesis, apoptosis …

TCR-engineered T cells have achieved great progress in solid tumor therapy, some of which
have been applicated in clinical trials. Deep knowledge about the current progress of TCR-T …

Inflammation is the human body's defence process against various pathogens, toxic
substances, irradiation, and physically injured cells that have been damaged. Inflammation …

Asymmetric catalytic processes promoted by N-heterocyclic carbenes (NHCs) hold great
potential for the sustainable preparation of chiral molecules. However, catalyzing the …

The stroma-rich variant of Castleman disease of hyaline-vascular type (SR-HVCD) is
characterized by interfollicular proliferation of the fibroblastic, myofibroblastic, and/or …

Abnormal Krüppel-like factor 11 (KLF11) expression is frequently found in tumor tissues and
is associated with cancer prognosis, but its biological functions and corresponding …

Abstract Murine double minute 2 (MDM2) and homologous protein murine double minute X
(MDMX) are p53 negative regulators that perform significant driving effects in tumorigenesis …

A green stereoselective synthesis of spiroheterocycles incorporating a spirooxindole and a
1, 2, 3, 4-tetrahydro-β-carboline (THβC) are demonstrated here by the one-pot, three …

In the current molecular review, we describe the mechanisms of TP53/MDM2 deregulation
and their impact on the colon adenocarcinoma molecular substrate and phenotype. Among …