Dysregulated RNA splicing is a molecular feature that characterizes almost all tumour types.
Cancer-associated splicing alterations arise from both recurrent mutations and altered …

The RNA-binding motif (RBM) proteins are a class of RNA-binding proteins named,
containing RNA-recognition motifs (RRMs), RNA-binding domains, and ribonucleoprotein …

De novo mutations are known to play a prominent role in sporadic disorders with reduced
fitness. We hypothesize that de novo mutations play an important role in severe male …

Lung cancer has the highest mortality rate of all cancers worldwide. Lung cancer is a very
heterogeneous disease that is often diagnosed at later stages which have a poor prognosis …

The RNA-binding motif protein RBM5 belongs to a family of multi-domain RNA binding
proteins that regulate alternative splicing of genes important for apoptosis and cell …

Understanding the mechanisms of pre-mRNA splicing is limited by the technical challenges
to examining spliceosomes in vivo. Here, we report the isolation of RNP complexes derived …

RBM10 is a nuclear RNA-binding protein (RBP) that regulates the alternative splicing of
primary transcripts. Recently, research on RBM10 has become increasingly active owing to …

Conclusion Collectively, the analysis of genetically modified and chemically induced animal
models of lung cancer has progressed the understanding of lung cancer pathogenesis …

The RNA-binding motif protein 10 (RBM10) is involved in alternative splicing and modifies
mRNA post-transcriptionally. RBM10 is abnormally expressed in the lung, breast, and …

Despite numerous studies on the mechanisms of cigarette smoking toxicity over the past
three decades, some aspects remain obscure. Recent developments have drawn attention …