The past several months have witnessed the emergence of SARS-CoV-2 variants with novel
spike protein mutations that are influencing the epidemiological and clinical aspects of the …

The novel human coronavirus disease COVID-19 has become the fifth documented
pandemic since the 1918 flu pandemic. COVID-19 was first reported in Wuhan, China, and …

Overcoming intrinsic resistance to immune checkpoint blockade for microsatellite stable
(MSS) colorectal cancer (CRC) and pancreatic ductal adenocarcinoma (PDAC) remains …

Understanding the trends in severe acute respiratory syndrome coronavirus 2 (SARS-CoV-
2) evolution is paramount to control the COVID-19 pandemic. We analyzed more than …

The patients with high microsatellite instability (MSI-H)/mismatch repair deficient (dMMR)
tumors recently have been reported that can benefit from immunotherapy, and MSI can be …

Checkpoint blockade immunotherapies enable the host immune system to recognize and
destroy tumour cells. Their clinical activity has been correlated with activated T-cell …

Dendritic cells (DCs) are essential in immunity owing to their role in activating T cells,
thereby promoting antitumor responses. Tumor cells, however, hijack the immune system …

In this study, we analyzed full-length SARS-CoV-2 genomes from multiple countries to
determine early trends in the evolutionary dynamics of the novel COVID-19 pandemic …

Forty years ago four research laboratories in London, Paris, New York/Bethesda, and
Princeton uncovered the existence of the p53 protein (Deleo et al., 1979; Lane and …

The COVID-19 outbreak has become a global emergency since December 2019. Analysis of
SARS-CoV-2 sequences can uncover single nucleotide variants (SNVs) and corresponding …