5-HT receptors expressed throughout the human body are targets for established
therapeutics and various drugs in development. Their diversity of structure and function …

Serotonin is a phylogenetically ancient biogenic amine that has played an integral role in
maintaining energy homeostasis for billions of years. In mammals, serotonin produced …

The enteric nervous system (ENS) is crucial for essential gastrointestinal physiologic
functions such as motility, fluid secretion, and blood flow. The gut is colonized by trillions of …

The gastrointestinal (GI) tract contains much of the body's serotonin (5-hydroxytryptamine, 5-
HT), but mechanisms controlling the metabolism of gut-derived 5-HT remain unclear. Here …

Neurotransmitters, including catecholamines and serotonin, play a crucial role in
maintaining homeostasis in the human body. Studies on these neurotransmitters mainly …

Tryptamine, a tryptophan-derived monoamine similar to 5-hydroxytryptamine (5-HT), is
produced by gut bacteria and is abundant in human and rodent feces. However, the …

Gut microbiota alterations have been described in several diseases with altered
gastrointestinal (GI) motility, and awareness is increasing regarding the role of the gut …

Abstract Serotonin (5-HT) has been recognized for decades as an important signalling
molecule in the gut, but it is still revealing its secrets. Novel gastrointestinal functions of 5-HT …

5-Hydroxytryptamine (serotonin) in the gastrointestinal trac... : Current Opinion in
Endocrinology, Diabetes and Obesity 5-Hydroxytryptamine (serotonin) in the …

Serotonin was first discovered in the gut, and its conventional actions as an intercellular
signalling molecule in the intrinsic and extrinsic enteric reflexes are well recognized, as are …