Natural products continue to be an important source of medicines and drug templates.
Indeed, it has been estimated that approximately a third of all Food and Drug Administration …

Background and Purpose GPCRs can signal through both G proteins and β‐arrestin2. For
the μ‐opioid receptor, early experimental evidence from a single study suggested that G …

Background and Purpose Cancer cells exhibit more dependence on iron and enhanced
sensitivity to iron‐dependent, programmed cell death (ferroptosis) than normal cells …

Background and Purpose Arctigenin, a major bioactive component of Fructus arctii, has
been reported to have antidepressant‐like effects. However, the mechanisms underlying …

Background and Purpose Short‐chain fatty acids (SCFAs) are metabolites from gut microbes
involved in the host's inflammatory response and immunity. The aim of this study was to …

Background and purpose Evidence indicates that ferroptosis plays a key role in acute kidney
injury induced by cisplatin. The Nrf2/NRF2 pathway regulates oxidative stress, lipid …

Background and Purpose Astrocytic nuclear factor erythroid‐derived 2‐related factor 2 (Nrf2)
is a potential therapeutic target of ischaemic preconditioning (IPC). Icariside II (ICS II) is a …

Background and Purpose Naringenin, a flavonoid compound with strong anti‐inflammatory
activity, attenuated non‐alcoholic fatty liver disease (NAFLD) induced by a methionine …

Background and Purpose Acute kidney injury is a common clinical problem with no definitive
or specific treatment. Therefore, the molecular mechanisms of acute kidney injury must be …

Background and Purpose Oxidative stress and neuronal apoptosis play key roles in
traumatic brain injury. We investigated the protective effects of astaxanthin against traumatic …