[HTML][HTML] Taurine: a maternally derived nutrient linking mother and offspring

S Tochitani - Metabolites, 2022 - mdpi.com
Mammals can obtain taurine from food and synthesize it from sulfur-containing amino acids.
Mammalian fetuses and infants have little ability to synthesize taurine. Therefore, they are …

[HTML][HTML] Taurine as an essential neuromodulator during perinatal cortical development

W Kilb, A Fukuda - Frontiers in cellular neuroscience, 2017 - frontiersin.org
A variety of experimental studies demonstrated that neurotransmitters are an important factor
for the development of the central nervous system, affecting neurodevelopmental events like …

[HTML][HTML] Administration of non-absorbable antibiotics to pregnant mice to perturb the maternal gut microbiota is associated with alterations in offspring behavior

S Tochitani, T Ikeno, T Ito, A Sakurai, T Yamauchi… - PloS one, 2016 - journals.plos.org
There is increasing evidence that the gut microbiota plays a major role in host health and
disease. In this study, we examined whether perturbation of the maternal gut microbiota …

Prenatal ethanol exposure disrupts intraneocortical circuitry, cortical gene expression, and behavior in a mouse model of FASD

H El Shawa, CW Abbott, KJ Huffman - Journal of Neuroscience, 2013 - Soc Neuroscience
In utero ethanol exposure from a mother9s consumption of alcoholic beverages impacts
brain and cognitive development, creating a range of deficits in the child (Levitt, 1998; Lebel …

Functions of maternally-derived taurine in fetal and neonatal brain development

S Tochitani - Taurine 10, 2017 - Springer
Abstract Taurine (2-aminoethanesulfonic acid) is a sulfur-containing organic acid, which has
various physiological functions, including membrane stabilization, cell-volume regulation …

GABAA Receptors and Maternally Derived Taurine Regulate the Temporal Specification of Progenitors of Excitatory Glutamatergic Neurons in the Mouse Developing …

S Tochitani, T Furukawa, R Bando, S Kondo… - Cerebral …, 2021 - academic.oup.com
Temporal specification of the neural progenitors (NPs) producing excitatory glutamatergic
neurons is essential for histogenesis of the cerebral cortex. Neuroepithelial cells, the primary …

[HTML][HTML] Exposure to GABAA Receptor Antagonist Picrotoxin in Pregnant Mice Causes Autism-Like Behaviors and Aberrant Gene Expression in Offspring

H Kotajima-Murakami, H Hagihara, A Sato… - Frontiers in …, 2022 - frontiersin.org
Autism spectrum disorder (ASD) is a neurodevelopmental disorder that is characterized by
impairments in social interaction and restricted/repetitive behaviors. The neurotransmitter γ …

Issues in assessing the health risks of n‐butanol

D Segal, AS Bale, LJ Phillips, A Sasso… - Journal of Applied …, 2020 - Wiley Online Library
A literature review and health effects evaluation were conducted for n‐butanol, a chemical
that occurs naturally in some foods, which is an intermediate in the production of butyl esters …

GABA System as the Cause and Effect in Early Development

I Topchiy, J Mohbat, OO Folorunso… - Neuroscience & …, 2024 - Elsevier
ABSTRACT GABA is the primary inhibitory neurotransmitter in the adult brain and through its
actions on GABAARs, it protects against excitotoxicity and seizure activity, ensures temporal …

[HTML][HTML] Immunoreactivity for GABA, GAD65, GAD67 and Bestrophin-1 in the meninges and the choroid plexus: implications for non-neuronal sources for GABA in the …

S Tochitani, S Kondo - PloS one, 2013 - journals.plos.org
Neural progenitors in the developing neocortex, neuroepithelial cells and radial glial cells,
have a bipolar shape with a basal process contacting the basal membrane of the meninge …