Melatonin is ubiquitous molecule with wide distribution in nature and is produced by many
living organisms. In human beings, pineal gland is the major site for melatonin production …

Multiple Sclerosis (MS) is considered the most frequent inflammatory demyelinating disease
of the central nervous system (CNS). It occurs with a variable prevalence across the world. A …

Humans evolved in sunlight and had depended on sunlight for its life giving properties that
was appreciated by our early ancestors. However, for more than 40 years the lay press and …

Autoimmune diseases are a range of diseases in which the immune response to self-
antigens results in damage or dysfunction of tissues. Autoimmune diseases can be systemic …

Although genetic susceptibility explains the clustering of multiple sclerosis (MS) within
families and the sharp decline in risk with increasing genetic distance, it cannot fully explain …

Melatonin modulates a wide range of physiological functions with pleiotropic effects on the
immune system. Despite the large number of reports implicating melatonin as an …

The most recent findings linking exposure to sun and vitamin D insufficiency to multiple
sclerosis (MS) are reviewed. Due to insufficient sunshine and changing lifestyles …

The Montreal Protocol has limited increases in the UV-B (280–315 nm) radiation reaching
the Earth's surface as a result of depletion of stratospheric ozone. Nevertheless, the …

The vitamin D receptor is expressed in multiple cells of the body (other than osteoblasts),
including beta cells and cells involved in immune modulation (such as mononuclear cells …

The last couple of decades have seen an explosion in our interest and understanding of the
role of vitamin D in the regulation of immunity. At the molecular level, the hormonal form of …