[HTML][HTML] The 2021 WHO classification of lung tumors: impact of advances since 2015

AG Nicholson, MS Tsao, MB Beasley… - Journal of Thoracic …, 2022 - Elsevier
Abstract The 2021 WHO Classification of Thoracic Tumours was published earlier this year,
with classification of lung tumors being one of the chapters. The principles remain those of …

Morphologic and molecular classification of lung neuroendocrine neoplasms

J Metovic, M Barella, F Bianchi, P Hofman, V Hofman… - Virchows Archiv, 2021 - Springer
Neuroendocrine neoplasms (NENs) of the lung encompass neuroendocrine tumors (NETs)
composed of typical (TC) and atypical (AC) carcinoids and full-fledged carcinomas (NECs) …

Druggable growth dependencies and tumor evolution analysis in patient-derived organoids of neuroendocrine neoplasms from multiple body sites

TL Dayton, N Alcala, L Moonen, L den Hartigh… - Cancer Cell, 2023 - cell.com
Neuroendocrine neoplasms (NENs) comprise well-differentiated neuroendocrine tumors
(NETs) and poorly differentiated neuroendocrine carcinomas (NECs). Treatment options for …

Lung and thymic carcinoids: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up☆

E Baudin, M Caplin, R Garcia-Carbonero… - Annals of …, 2021 - annalsofoncology.org
The latest World Health Organization (WHO) classification from 2015 has grouped lung and
thymic neuroendocrine tumours (NETs)(named neoplasm in the digestive WHO …

Integrative and comparative genomic analyses identify clinically relevant pulmonary carcinoid groups and unveil the supra-carcinoids

N Alcala, N Leblay, AAG Gabriel, L Mangiante… - Nature …, 2019 - nature.com
The worldwide incidence of pulmonary carcinoids is increasing, but little is known about
their molecular characteristics. Through machine learning and multi-omics factor analysis …

Classification of neuroendocrine neoplasms: lights and shadows

S La Rosa, S Uccella - Reviews in endocrine and metabolic disorders, 2021 - Springer
Neuroendocrine neoplasms (NENs) are a heterogeneous group of neoplastic proliferations
showing different morphological features, immunophenotype, molecular background …

[HTML][HTML] New molecular classification of large cell neuroendocrine carcinoma and small cell lung carcinoma with potential therapeutic impacts

S Lantuejoul, L Fernandez-Cuesta… - … lung cancer research, 2020 - ncbi.nlm.nih.gov
Large cell neuroendocrine carcinoma (LCNECs) and small cell lung carcinomas (SCLCs)
are high-grade neuroendocrine carcinomas of the lung with very aggressive behavior and …

Genomics of high-grade neuroendocrine neoplasms: well-differentiated neuroendocrine tumor with high-grade features (G3 NET) and neuroendocrine carcinomas …

S Uccella, S La Rosa, J Metovic, D Marchiori… - Endocrine …, 2021 - Springer
High-grade neuroendocrine neoplasms (HG-NENs) are clinically aggressive diseases, the
classification of which has recently been redefined. They now include both poorly …

Large cell neuroendocrine carcinoma of the lung: current understanding and challenges

E Andrini, PV Marchese, D De Biase… - Journal of Clinical …, 2022 - mdpi.com
Large cell neuroendocrine carcinoma of the lung (LCNEC) is a rare and highly aggressive
type of lung cancer, with a complex biology that shares similarities with both small-cell lung …

[HTML][HTML] Clinical-pathologic challenges in the classification of pulmonary neuroendocrine neoplasms and targets on the horizon for future clinical practice

JL Derks, N Rijnsburger, BCM Hermans… - Journal of Thoracic …, 2021 - Elsevier
Diagnosing a pulmonary neuroendocrine neoplasm (NEN) may be difficult, challenging
clinical decision making. In this review key clinical and pathological issues and informative …