Polypeptides have attracted considerable attention in recent decades due to their inherent
biodegradability and tunable cytocompatibility. Macromolecular design in conjunction with …

Polymers consisting of amino acid building blocks continue to receive consideration for
biomedical applications. Since poly (amino acid) s are built from natural amino acids, the …

Multifunctional nanocarriers are increasingly promising for disease treatment aimed to
regulate multiple pathological dysfunctions and overcome barriers in drug delivery. Here we …

Delivery of macromolecular drugs to the brain is impeded by the blood brain barrier. The
recruitment of leukocytes to lesions in the brain, a typical feature of neuroinflammation …

Purpose To prepare an angiopep-conjugated dendrigraft poly-L-lysine (DGL)-based gene
delivery system and evaluate the neuroprotective effects in the rotenone-induced chronic …

The blood–brain barrier is the major obstacle that prevents diagnostic and therapeutic drugs
being delivered to the central nervous systems in order to exert their effects. Specific ligand …

Importance of the field: The review presents the design strategy and synthesis of
multifunctional dendrimers and hyperbranched polymers with the objective to develop …

Polylysine is an important class of polyamino acids with a broad spectrum of applications in
biomedical research and development. It can be divided into two classes, α-polylysine and ε …

Vaccination is the most cost-effective and sustainable way to prevent and eliminate
infectious diseases. Compared with traditional vaccines, novel vaccines have better stability …

Poly (amidoamine)(PAMAM) dendrimer nanobiotechnology shows great promise in targeted
drug delivery and gene therapy. Because of the involvement of cell membrane lipids with the …