Identification of RNA structures and their roles in RNA functions
The development of high-throughput RNA structure profiling methods in the past decade has
greatly facilitated our ability to map and characterize different aspects of RNA structures …
greatly facilitated our ability to map and characterize different aspects of RNA structures …
Metal cations in G-quadruplex folding and stability
D Bhattacharyya, G Mirihana Arachchilage… - Frontiers in …, 2016 - frontiersin.org
This review is focused on the structural and physicochemical aspects of metal cation
coordination to G-Quadruplexes (GQ) and their effects on GQ stability and conformation. G …
coordination to G-Quadruplexes (GQ) and their effects on GQ stability and conformation. G …
Detection of G-quadruplex DNA in mammalian cells
A Henderson, Y Wu, YC Huang, EA Chavez… - Nucleic acids …, 2013 - academic.oup.com
It has been proposed that guanine-rich DNA forms four-stranded structures in vivo called G-
quadruplexes or G4 DNA. G4 DNA has been implicated in several biological processes, but …
quadruplexes or G4 DNA. G4 DNA has been implicated in several biological processes, but …
Solution structure of the human telomeric repeat d [AG3 (T2AG3) 3] G-tetraplex
Background: Repeats of O n sequences are detected as single strand overhangs at the ends
of eukaryotic chromosomes together with associated binding proteins. Such telomere …
of eukaryotic chromosomes together with associated binding proteins. Such telomere …
G‐quartets 40 years later: from 5′‐GMP to molecular biology and supramolecular chemistry
JT Davis - Angewandte Chemie International Edition, 2004 - Wiley Online Library
Molecular self‐assembly is central to many processes in both biology and supramolecular
chemistry. The G‐quartet, a hydrogen‐bonded macrocycle formed by cation‐templated …
chemistry. The G‐quartet, a hydrogen‐bonded macrocycle formed by cation‐templated …
5′-UTR RNA G-quadruplexes: translation regulation and targeting
A Bugaut, S Balasubramanian - Nucleic acids research, 2012 - academic.oup.com
RNA structures in the untranslated regions (UTRs) of mRNAs influence post-transcriptional
regulation of gene expression. Much of the knowledge in this area depends on canonical …
regulation of gene expression. Much of the knowledge in this area depends on canonical …
Thrombin-binding DNA aptamer forms a unimolecular quadruplex structure in solution.
RF Macaya, P Schultze, FW Smith… - Proceedings of the …, 1993 - National Acad Sciences
We have used two-dimensional 1H NMR spectroscopy to study the conformation of the
thrombin-binding aptamer d (GGTTGGTGTGGTTGG) in solution. This is one of a series of …
thrombin-binding aptamer d (GGTTGGTGTGGTTGG) in solution. This is one of a series of …
Human telomere, oncogenic promoter and 5′-UTR G-quadruplexes: diverse higher order DNA and RNA targets for cancer therapeutics
Guanine-rich DNA sequences can form G-quadruplexes stabilized by stacked G–G–G–G
tetrads in monovalent cation-containing solution. The length and number of individual G …
tetrads in monovalent cation-containing solution. The length and number of individual G …
G-quadruplex formation within the promoter of the KRAS proto-oncogene and its effect on transcription
S Cogoi, LE Xodo - Nucleic acids research, 2006 - academic.oup.com
In human and mouse, the promoter of the KRAS gene contains a nuclease hypersensitive
polypurine–polypyrimidine element (NHPPE) that is essential for transcription. An interesting …
polypurine–polypyrimidine element (NHPPE) that is essential for transcription. An interesting …
The diverse structural landscape of quadruplexes
G‐quadruplexes are secondary structures formed in G‐rich sequences in DNA and RNA.
Considerable research over the past three decades has led to in‐depth insight into these …
Considerable research over the past three decades has led to in‐depth insight into these …