New avenues for the treatment of Huntington's disease
A Kim, K Lalonde, A Truesdell, P Gomes Welter… - International journal of …, 2021 - mdpi.com
Huntington's disease (HD) is a neurodegenerative disorder caused by a CAG expansion in
the HD gene. The disease is characterized by neurodegeneration, particularly in the striatum …
the HD gene. The disease is characterized by neurodegeneration, particularly in the striatum …
A phase 2 double-blind placebo-controlled 24-week treatment clinical study of the p38 alpha kinase inhibitor neflamapimod in mild Alzheimer's disease
ND Prins, JE Harrison, HM Chu, K Blackburn… - Alzheimer's research & …, 2021 - Springer
Background In preclinical studies, p38⍺ kinase is implicated in Alzheimer's disease (AD)
pathogenesis. In animal models, it mediates impaired synaptic dysfunction in the …
pathogenesis. In animal models, it mediates impaired synaptic dysfunction in the …
Synaptic Plasticity and Its Uses
S Ranjan, S Dwivedi, S Singh - Synaptic Plasticity in …, 2024 - taylorfrancis.com
The brain's process of learning and memory formation is primarily driven by synaptic
plasticity, which is the capacity of synapses to become stronger or weaker over time in …
plasticity, which is the capacity of synapses to become stronger or weaker over time in …