Small molecule inhibitors targeting the cancers
Compared with traditional therapies, targeted therapy has merits in selectivity, efficacy, and
tolerability. Small molecule inhibitors are one of the primary targeted therapies for cancer …
tolerability. Small molecule inhibitors are one of the primary targeted therapies for cancer …
Recent drug design strategies and identification of key heterocyclic scaffolds for promising anticancer targets
Cancer, a noncommunicable disease, is the leading cause of mortality worldwide and is
anticipated to rise by 75% in the next two decades, reaching approximately 25 million cases …
anticipated to rise by 75% in the next two decades, reaching approximately 25 million cases …
Small molecule '4ab'induced autophagy and endoplasmic reticulum stress-mediated death of aggressive cancer cells grown under adherent and floating conditions
Metastasis is the leading cause of death in cancer patients and a major challenging aspect
of cancer biology. Various adaptive molecular signaling pathways play a crucial role in …
of cancer biology. Various adaptive molecular signaling pathways play a crucial role in …
[HTML][HTML] Baicalin induces apoptosis and autophagy in human osteosarcoma cells by increasing ROS to inhibit PI3K/Akt/mTOR, ERK1/2 and β-catenin signaling …
H Pang, T Wu, Z Peng, Q Tan, X Peng, Z Zhan… - Journal of Bone …, 2022 - Elsevier
Baicalin, a flavonoid derivative, exerts antitumor activity in a variety of neoplasms. However,
whether baicalin exerts antitumor effects on osteosarcoma cells remains to be elucidated. In …
whether baicalin exerts antitumor effects on osteosarcoma cells remains to be elucidated. In …
Recent progress in CDK4/6 inhibitors and PROTACs
H Wang, J Ba, Y Kang, Z Gong, T Liang, Y Zhang, J Qi… - Molecules, 2023 - mdpi.com
Cell division in eukaryotes is a highly regulated process that is critical to the life of a cell.
Dysregulated cell proliferation, often driven by anomalies in cell Cyclin-dependent kinase …
Dysregulated cell proliferation, often driven by anomalies in cell Cyclin-dependent kinase …
FBXW7 in breast cancer: mechanism of action and therapeutic potential
S Chen, P Leng, J Guo, H Zhou - Journal of Experimental & Clinical …, 2023 - Springer
Breast cancer is one of the frequent tumors that seriously endanger the physical and mental
well-being in women. F-box and WD repeat domain-containing 7 (FBXW7) is a neoplastic …
well-being in women. F-box and WD repeat domain-containing 7 (FBXW7) is a neoplastic …
Scopoletin: anticancer potential and mechanism of action
L Meilawati, RM Dewi, AN Tasfiyati… - Asian Pacific Journal …, 2023 - journals.lww.com
Cancer is considered a leading cause of death worldwide due to its high morbidity and
mortality rate. Conventional treatments for cancer therapy, such as chemotherapy, and …
mortality rate. Conventional treatments for cancer therapy, such as chemotherapy, and …
Platycodin-D exerts its anti-cancer effect by promoting c-Myc protein ubiquitination and degradation in gastric cancer
Q Xu, G Pan, Z Wang, L Wang, Y Tang… - Frontiers in …, 2023 - frontiersin.org
Platycodin D (PD) is a triterpene saponin extracted from the root of Platycodon grandiflorum.
It has been reported to exhibit multiple pharmacological and biological properties. There is …
It has been reported to exhibit multiple pharmacological and biological properties. There is …
Synergistic anticancer effect by targeting CDK2 and EGFR–ERK signaling
J Wu, Y Chen, R Li, Y Guan, M Chen, H Yin… - Journal of Cell …, 2023 - rupress.org
The EGFR-RAS-ERK pathway is one of the most important signaling cascades in cell
survival, growth, and proliferation. Aberrant activation of this pathway is a common …
survival, growth, and proliferation. Aberrant activation of this pathway is a common …
[HTML][HTML] Gold Nanobiosensors: Pioneering Breakthroughs in Precision Breast Cancer Detection
S Sadr, A Hajjafari, A Rahdar, S Pandey… - European Journal of …, 2024 - Elsevier
Breast cancer is still one of the major health concerns of today's world. In light of such a
scenario, regular improvement in the detection technique is crucial to meet better early …
scenario, regular improvement in the detection technique is crucial to meet better early …