Small molecule inhibitors targeting the cancers

GH Liu, T Chen, X Zhang, XL Ma, HS Shi - MedComm, 2022 - Wiley Online Library
Compared with traditional therapies, targeted therapy has merits in selectivity, efficacy, and
tolerability. Small molecule inhibitors are one of the primary targeted therapies for cancer …

Recent drug design strategies and identification of key heterocyclic scaffolds for promising anticancer targets

A Mushtaq, P Wu, MM Naseer - Pharmacology & Therapeutics, 2024 - Elsevier
Cancer, a noncommunicable disease, is the leading cause of mortality worldwide and is
anticipated to rise by 75% in the next two decades, reaching approximately 25 million cases …

Small molecule '4ab'induced autophagy and endoplasmic reticulum stress-mediated death of aggressive cancer cells grown under adherent and floating conditions

SU Khan, K Fatima, U Singh, PP Singh, F Malik - Medical Oncology, 2023 - Springer
Metastasis is the leading cause of death in cancer patients and a major challenging aspect
of cancer biology. Various adaptive molecular signaling pathways play a crucial role in …

[HTML][HTML] Baicalin induces apoptosis and autophagy in human osteosarcoma cells by increasing ROS to inhibit PI3K/Akt/mTOR, ERK1/2 and β-catenin signaling …

H Pang, T Wu, Z Peng, Q Tan, X Peng, Z Zhan… - Journal of Bone …, 2022 - Elsevier
Baicalin, a flavonoid derivative, exerts antitumor activity in a variety of neoplasms. However,
whether baicalin exerts antitumor effects on osteosarcoma cells remains to be elucidated. In …

Recent progress in CDK4/6 inhibitors and PROTACs

H Wang, J Ba, Y Kang, Z Gong, T Liang, Y Zhang, J Qi… - Molecules, 2023 - mdpi.com
Cell division in eukaryotes is a highly regulated process that is critical to the life of a cell.
Dysregulated cell proliferation, often driven by anomalies in cell Cyclin-dependent kinase …

FBXW7 in breast cancer: mechanism of action and therapeutic potential

S Chen, P Leng, J Guo, H Zhou - Journal of Experimental & Clinical …, 2023 - Springer
Breast cancer is one of the frequent tumors that seriously endanger the physical and mental
well-being in women. F-box and WD repeat domain-containing 7 (FBXW7) is a neoplastic …

Scopoletin: anticancer potential and mechanism of action

L Meilawati, RM Dewi, AN Tasfiyati… - Asian Pacific Journal …, 2023 - journals.lww.com
Cancer is considered a leading cause of death worldwide due to its high morbidity and
mortality rate. Conventional treatments for cancer therapy, such as chemotherapy, and …

Platycodin-D exerts its anti-cancer effect by promoting c-Myc protein ubiquitination and degradation in gastric cancer

Q Xu, G Pan, Z Wang, L Wang, Y Tang… - Frontiers in …, 2023 - frontiersin.org
Platycodin D (PD) is a triterpene saponin extracted from the root of Platycodon grandiflorum.
It has been reported to exhibit multiple pharmacological and biological properties. There is …

Synergistic anticancer effect by targeting CDK2 and EGFR–ERK signaling

J Wu, Y Chen, R Li, Y Guan, M Chen, H Yin… - Journal of Cell …, 2023 - rupress.org
The EGFR-RAS-ERK pathway is one of the most important signaling cascades in cell
survival, growth, and proliferation. Aberrant activation of this pathway is a common …

[HTML][HTML] Gold Nanobiosensors: Pioneering Breakthroughs in Precision Breast Cancer Detection

S Sadr, A Hajjafari, A Rahdar, S Pandey… - European Journal of …, 2024 - Elsevier
Breast cancer is still one of the major health concerns of today's world. In light of such a
scenario, regular improvement in the detection technique is crucial to meet better early …