Nitroxide radical polymers–a versatile material class for high-tech applications

KA Hansen, JP Blinco - Polymer Chemistry, 2018 - pubs.rsc.org
Nitroxides are a versatile class of stable free radicals that have long established themselves
in a wide range of applications. Their incorporation into macromolecular architectures has …

Opportunities for organocatalysis in polymer synthesis via step-growth methods

A Bossion, KV Heifferon, L Meabe, N Zivic… - Progress in Polymer …, 2019 - Elsevier
Organocatalysis has emerged as an invaluable tool for polymer synthesis and has already
demonstrated versatility for replacing organometallic catalysts in many polymerization …

Macromolecular architectures through organocatalysis

S Hu, J Zhao, G Zhang, H Schlaad - Progress in Polymer Science, 2017 - Elsevier
In virtue of the rising demand for metal-free polymeric materials, organocatalytic
polymerization has emerged and blossomed unprecedentedly in the past 15 years into an …

Triply loaded nitroxide brush-arm star polymers enable metal-free millimetric tumor detection by magnetic resonance imaging

HVT Nguyen, A Detappe, NM Gallagher, H Zhang… - ACS …, 2018 - ACS Publications
Nitroxides occupy a privileged position among plausible metal-free magnetic resonance
imaging (MRI) contrast agents (CAs) due to their inherently low-toxicity profiles; …

Polyoxazoline-based bottlebrush and brush-arm star polymers via ROMP: syntheses and applications as organic radical contrast agents

GG Alvaradejo, HVT Nguyen, P Harvey… - ACS macro …, 2019 - ACS Publications
The synthesis of functional poly (2-alkyl-2-oxazoline)(PAOx) copolymers with complex
nanoarchitectures using a graft-through ring-opening metathesis polymerization (ROMP) …

The Transition from Metal-Based to Metal-Free Contrast Agents for T1 Magnetic Resonance Imaging Enhancement

OU Akakuru, MZ Iqbal, M Saeed, C Liu… - Bioconjugate …, 2019 - ACS Publications
Magnetic resonance imaging (MRI) has received significant attention as the noninvasive
diagnostic technique for complex diseases. Image-guided therapeutic strategy for diseases …

Functional polymers as metal-free magnetic resonance imaging contrast agents

C Fu, Y Yu, X Xu, Q Wang, Y Chang, C Zhang… - Progress in Polymer …, 2020 - Elsevier
Magnetic resonance imaging (MRI) is recognized as the most powerful clinical imaging
modality due to its ability to generate detailed three-dimensional anatomical images with …

Metal-free organo-theranostic nanosystem with high nitroxide stability and loading for image-guided targeted tumor therapy

OU Akakuru, C Xu, C Liu, Z Li, J Xing, C Pan, Y Li… - ACS …, 2021 - ACS Publications
The desire for all-organic-composed nanoparticles (NPs) of considerable biocompatibility to
simultaneously diagnose and treat cancer is undeniably interminable. Heretofore, metal …

Enhancing the efficacy of metal‐free MRI contrast agents via conjugating nitroxides onto PEGylated cross‐linked poly (carboxylate ester)

S Guo, X Wang, Y Dai, X Dai, Z Li, Q Luo… - Advanced …, 2020 - Wiley Online Library
Herein, two water‐soluble PROXYL‐based magnetic resonance imaging (MRI)
macromolecular organic contrast agents (mORCAs) are designed and synthesized: linear …

Nitroxyl modified tobacco mosaic virus as a metal-free high-relaxivity MRI and EPR active superoxide sensor

M Dharmarwardana, AF Martins, Z Chen… - Molecular …, 2018 - ACS Publications
Superoxide overproduction is known to occur in multiple disease states requiring critical
care; yet, noninvasive detection of superoxide in deep tissue remains a challenge. Herein …