A Comprehensive Review on l-Asparaginase and Its Applications

T Batool, EA Makky, M Jalal, MM Yusoff - Applied biochemistry and …, 2016 - Springer
Abstract l-asparaginase (LA) catalyzes the degradation of asparagine, an essential amino
acid for leukemic cells, into ammonia and aspartate. Owing to its ability to inhibit protein …

Marine Streptomyces as a novel source of bioactive substances

S Dharmaraj - World Journal of Microbiology and Biotechnology, 2010 - Springer
Marine actinobacteria are the most economically as well as biotechnologically valuable
prokaryotes. Representative genera of marine actinobacteria include Actinomadura …

Purification, characterization, cytotoxicity and anticancer activities of L-asparaginase, anti-colon cancer protein, from the newly isolated alkaliphilic Streptomyces …

NEA El-Naggar, SF Deraz, HM Soliman, NM El-Deeb… - Scientific reports, 2016 - nature.com
L-asparaginase is an important enzyme as therapeutic agents used in combination with
other drugs in the treatment of acute lymphoblastic leukemia. A newly isolated …

L-asparaginase–A promising biocatalyst for industrial and clinical applications

G Shakambari, B Ashokkumar… - Biocatalysis and …, 2019 - Elsevier
L-asparaginase is a versatile enzyme with application in food and therapeutics and under
constant quest for a reliable microbial source for commercial production. The review is an …

Study of L-asparaginase production by Streptomyces noursei MTCC 10469, isolated from marine sponge Callyspongia diffusa

S Dharmaraj - Iranian journal of biotechnology, 2011 - ijbiotech.com
L-asparaginase is an anti-neoplastic agent used in the chemotherapy of lymphoblastic
leukaemia. The present work deals with production of extra-cellular Lasparaginase from …

[PDF][PDF] Efficient production of L-asparaginase by marine Streptomyces sp. isolated from Bay of Bengal, India

P Sivasankar, S Sugesh, P Vijayanand… - Afr J Microbiol …, 2013 - researchgate.net
Pharmaceutical industries are in need for new class of antibiotics from cheaper and safer
sources due to alarming occurrence of multiple-drug resistant pathogens. Recently, marine …

[PDF][PDF] Isolation and purification of high efficiency L-asparaginase by quantitative preparative continuous-elution SDS PAGE electrophoresis

M Senthil Kumar, K Selvam - J Microbial Biochem …, 2011 - drngpasclibrary.pbworks.com
An Unique extracelluar glutaminase free L-asparaginase from novel marine Actinomycetes
was isolated to perceptible homogeneity in agro industrial wastes. Quantitative Preparative …

[PDF][PDF] L-Asparaginase produced by Streptomyces strain isolated from Egyptian soil: Purification, characterization and evaluation of its anti-tumor

SM El-Sabbagh, NH El-Batanony… - Afr J Microbiol …, 2013 - pdfs.semanticscholar.org
L-Asparaginase (EC 3.5. 1.1) is the first enzyme with antitumor activity intensively studied in
human beings (Savitri and Azmi, 2003). It is used for the treatment of malignancies of the …

Isolation and characterization of antagonistic actinobacteria from mangrove soil.

KV Rao, DB Rao, TR Rao - Journal of Biochemical …, 2012 - search.ebscohost.com
The aim of the present study was to isolate and screen actinobacteria having antagonistic
activities against pathogenic microorganisms. A total of twenty actinobacteria strains were …

A Comprehensive Review of L-Asparaginase: Production, Applications and Therapeutic Potential in Cancer Treatment

K Hosseini, T Zivari-Ghader, P Akbarzadehlaleh… - Applied Biochemistry …, 2024 - Springer
Abstract L-Asparaginase (EC 3.5. 1.1) primarily catalyzes the hydrolysis of Asn into
ammonium and L-Asp and has wide applications in various industrial sectors. This protein …