Proteases are signaling molecules that specifically control cellular functions by cleaving
protease-activated receptors (PARs). The four known PARs are members of the large family …

Nitric oxide (NO) is a powerful biological mediator provided with a number of activities of
relevance for the prevention of thrombosis, like vasodilation, inhibition of platelet adhesion …

Megakaryocytes transfer a diverse and functional transcriptome to platelets during the final
stages of thrombopoiesis. In platelets, these transcripts reflect the expression of their …

The mechanisms through which moderate wine consumption reduces ischemic
cardiovascular events are not yet fully unraveled. Grape extracts or a mixture of the …

Rationale: Platelets are essential for pulmonary leukocyte recruitment, airway
hyperresponsiveness, and bronchial remodeling in animals with allergic inflammation and …

Platelets contain and release matrix metalloproteinases (MMPs), their inhibitors (TIMPs) and
disintegrin metalloproteinases (ADAMs) including MMP-1, MMP-2, MMP-3, MMP-9, MT1 …

Integrin αIIbβ3 activation is essential for platelet aggregation and, accordingly, for
hemostasis and arterial thrombosis. The αIIbβ3 integrin is highly expressed on platelets and …

Irrefutable clinical evidence demonstrates the activation of platelets in allergic diseases,
including asthma, allergic rhinitis, and eczema. Indeed, experimental models of allergic …

Summary Background: Interaction of murine Gas6 with the platelet Gas6 receptors Tyro3,
Axl and Mer (TAM) plays an important role in arterial thrombus formation. However, a role for …

Although lacking a nucleus, platelets are increasingly recognized not only for their
complexity, but also for their diversity. Some 50 years ago platelet subpopulations were …