Exposure to particulate silica (most crystalline polymorphs) causes a persistent inflammation
sustained by the release of oxidants in the alveolar space. Reactive oxygen species (ROS) …

Interstitial pulmonary fibrosis caused by the inhalation of asbestos fibers or silica particles
continues to be an important cause of interstitial lung disease. Although more stringent …

During the past decade a plethora of studies have unravelled the multiple roles of nitric
oxide (NO) in airway physiology and pathophysiology. In the respiratory tract, NO is …

Inhalation of the crystalline form of silica is associated with a variety of pathologies, from
acute lung inflammation to silicosis, in addition to autoimmune disorders and cancer. Basic …

Background Altered patterns of gene expression mediate the effects of particulate matter
(PM) on human health, but mechanisms through which PM modifies gene expression are …

This study investigated the in vivo pulmonary toxicity of inhaled multi-walled carbon
nanotubes (MWCNT). Mice-inhaled aerosolized MWCNT (10 mg/m3, 5 h/day) for 2, 4, 8 or …

Peroxynitrite is a reactive oxidant produced from nitric oxide (NO) and superoxide. Although
its reactivity and decomposition are very much dependent on the constituents of the cellular …

Silicosis is the most common pneumoconiosis globally, with higher prevalence and
incidence in developing countries. To date, there is no effective treatment to halt or reverse …

Fibrosis is characterized by excessive accumulation of extracellular matrix (ECM) in
basement membranes and interstitial tissues, resulting from increased synthesis or …

Nitric oxide (NO) is an important endogenous neurotransmitter and mediator. It participates
in regulation of physiological processes in different organ systems including airways …