The CNS is endowed with an elaborated response repertoire termed'neuroinflammation',
which enables it to cope with pathogens, toxins, traumata and degeneration. On the basis of …

Although glutamate is one of the most important excitatory neurotransmitters of the central
nervous system, its excessive extracellular concentration leads to uncontrolled continuous …

Microglia are the primary mediators of the immune defense system of the CNS and are
integral to the subsequent inflammatory response. The role of microglia in the injured CNS is …

This review considers the pathobiology of non-impact blast-induced neurotrauma (BINT).
The pathobiology of traumatic brain injury (TBI) has been historically studied in experimental …

Since the original identification of microglia as a principal player in the brain's innate
immune response, microglial activation has been widely studied. Recent studies suggest …

Microglia are the resident innate immune cells of the central nervous system that mediate
brain homeostasis maintenance. Microglia-mediated neuroinflammation is a hallmark …

Cell death after traumatic brain injury (TBI) is a major cause of neurological deficits and
mortality. Understanding the mechanisms of delayed post-traumatic cell loss may lead to …

In vitro models of traumatic brain injury (TBI) are helping elucidate the pathobiological
mechanisms responsible for dysfunction and delayed cell death after mechanical stimulation …

Approximately 1.7 million people in the United States annually experience a traumatic brain
injury (TBI). 1 The number of unreported head injuries is much higher. Sports-related head …

J. Neurochem.(2010) 112, 1099–1114. Abstract Among multiple structural and functional
brain changes, aging is accompanied by an increase of inflammatory signaling in the …