Strategies and Mechanisms of First-Row Transition Metal-Regulated Radical C–H Functionalization
X Wang, J He, YN Wang, Z Zhao, K Jiang… - Chemical …, 2024 - ACS Publications
Radical C–H functionalization represents a useful means of streamlining synthetic routes by
avoiding substrate preactivation and allowing access to target molecules in fewer steps. The …
avoiding substrate preactivation and allowing access to target molecules in fewer steps. The …
Metalloradical Catalysis: General Approach for Controlling Reactivity and Selectivity of Homolytic Radical Reactions
Since Friedrich Wöhler's groundbreaking synthesis of urea in 1828, organic synthesis over
the past two centuries has predominantly relied on the exploration and utilization of …
the past two centuries has predominantly relied on the exploration and utilization of …
Iron-Catalyzed Intermolecular C–N Cross-Coupling Reactions via Radical Activation Mechanism
A concept for intermolecular C–N cross-coupling amination has been discovered using
tetrazoles and aromatic and aliphatic azides with boronic acids under iron-catalyzed …
tetrazoles and aromatic and aliphatic azides with boronic acids under iron-catalyzed …
Intermolecular Enantioselective Benzylic C(sp3)−H Amination by Cationic Copper Catalysis**
L Dai, YY Chen, LJ Xiao… - Angewandte Chemie …, 2023 - Wiley Online Library
Chiral benzylic amines are privileged motifs in pharmacologically active molecules.
Intramolecular enantioselective radical C (sp3)− H functionalization by hydrogen‐atom …
Intramolecular enantioselective radical C (sp3)− H functionalization by hydrogen‐atom …
Direct synthesis of branched amines enabled by dual-catalyzed allylic C─ H amination of alkenes with amines
Direct conversion of hydrocarbons into amines represents an important and atom-economic
goal in chemistry for decades. However, intermolecular cross-coupling of terminal alkenes …
goal in chemistry for decades. However, intermolecular cross-coupling of terminal alkenes …
Asymmetric radical bicyclization for stereoselective construction of tricyclic chromanones and chromanes with fused cyclopropanes
Asymmetric radical bicyclization processes have been developed via metalloradical
catalysis (MRC) to stereoselectively construct chiral chromanones and chromanes bearing …
catalysis (MRC) to stereoselectively construct chiral chromanones and chromanes bearing …
New mode of asymmetric induction for enantioselective radical N-heterobicyclization via kinetically stable chiral radical center
Enantioselective radical N-heterobicyclization of N-allylsulfamoyl azides has been
developed via metalloradical catalysis (MRC). The Co (II)-based catalytic system can …
developed via metalloradical catalysis (MRC). The Co (II)-based catalytic system can …
Iron‐Catalyzed Intermolecular C− H Amination Assisted by an Isolated Iron‐Imido Radical Intermediate
Here we report the use of a base metal complex [(tBupyrpyrr2) Fe (OEt2)](1‐
OEt2)(tBupyrpyrr22−= 3, 5‐tBu2‐bis (pyrrolyl) pyridine) as a catalyst for intermolecular …
OEt2)(tBupyrpyrr22−= 3, 5‐tBu2‐bis (pyrrolyl) pyridine) as a catalyst for intermolecular …
Palladium(II)‐Catalyzed Nondirected Late‐Stage C(sp2)−H Deuteration of Heteroarenes Enabled Through a Multi‐Substrate Screening Approach
J Dey, S Kaltenberger… - Angewandte Chemie …, 2024 - Wiley Online Library
The importance of deuterium labelling in a variety of applications, ranging from mechanistic
studies to drug‐discovery, has spurred immense interest in the development of new …
studies to drug‐discovery, has spurred immense interest in the development of new …
Electrochemical Oxidative C–H Amination through a Ritter-Type Reaction
Y Xu, Q Li, R Ye, B Xu, X Zhou - The Journal of Organic Chemistry, 2023 - ACS Publications
A straightforward strategy for direct benzylic C–H bond amination via an electrochemical
Ritter-type reaction is developed. The reaction demonstrates simpler and milder reaction …
Ritter-type reaction is developed. The reaction demonstrates simpler and milder reaction …