Can we predict T cell specificity with digital biology and machine learning?
Recent advances in machine learning and experimental biology have offered breakthrough
solutions to problems such as protein structure prediction that were long thought to be …
solutions to problems such as protein structure prediction that were long thought to be …
T cell antigen discovery
AV Joglekar, G Li - Nature methods, 2021 - nature.com
T cells respond to threats in an antigen-specific manner using T cell receptors (TCRs) that
recognize short peptide antigens presented on major histocompatibility complex (MHC) …
recognize short peptide antigens presented on major histocompatibility complex (MHC) …
Structure-based prediction of T cell receptor: peptide-MHC interactions
P Bradley - Elife, 2023 - elifesciences.org
The regulatory and effector functions of T cells are initiated by the binding of their cell-
surface T cell receptor (TCR) to peptides presented by major histocompatibility complex …
surface T cell receptor (TCR) to peptides presented by major histocompatibility complex …
Prediction of neo-epitope immunogenicity reveals TCR recognition determinants and provides insight into immunoediting
J Schmidt, AR Smith, M Magnin, J Racle, JR Devlin… - Cell Reports …, 2021 - cell.com
CD8+ T cell recognition of peptide epitopes plays a central role in immune responses
against pathogens and tumors. However, the rules that govern which peptides are truly …
against pathogens and tumors. However, the rules that govern which peptides are truly …
Structural and physical features that distinguish tumor-controlling from inactive cancer neoepitopes
JM Custodio, CM Ayres, TJ Rosales… - Proceedings of the …, 2023 - National Acad Sciences
Neoepitopes arising from amino acid substitutions due to single nucleotide polymorphisms
are targets of T cell immune responses to cancer and are of significant interest in the …
are targets of T cell immune responses to cancer and are of significant interest in the …
Structure-based prediction of T cell receptor recognition of unseen epitopes using TCRen
VK Karnaukhov, DS Shcherbinin… - Nature Computational …, 2024 - nature.com
T cell receptor (TCR) recognition of foreign peptides presented by major histocompatibility
complex protein is a major event in triggering the adaptive immune response to pathogens …
complex protein is a major event in triggering the adaptive immune response to pathogens …
Using T cell receptor repertoires to understand the principles of adaptive immune recognition
Adaptive immune recognition is mediated by antigen receptors on B and T cells generated
by somatic recombination during lineage development. The high level of diversity resulting …
by somatic recombination during lineage development. The high level of diversity resulting …
Predicting antigen specificity of single T cells based on TCR CDR 3 regions
It has recently become possible to simultaneously assay T‐cell specificity with respect to
large sets of antigens and the T‐cell receptor sequence in high‐throughput single‐cell …
large sets of antigens and the T‐cell receptor sequence in high‐throughput single‐cell …
TCR-BERT: learning the grammar of T-cell receptors for flexible antigen-binding analyses
The T-cell receptor (TCR) allows T-cells to recognize and respond to antigens presented by
infected and diseased cells. However, due to TCRs' staggering diversity and the complex …
infected and diseased cells. However, due to TCRs' staggering diversity and the complex …
Structure based prediction of neoantigen immunogenicity
TP Riley, GLJ Keller, AR Smith, LM Davancaze… - Frontiers in …, 2019 - frontiersin.org
The development of immunological therapies that incorporate peptide antigens presented to
T cells by MHC proteins is a long sought-after goal, particularly for cancer, where mutated …
T cells by MHC proteins is a long sought-after goal, particularly for cancer, where mutated …