Strategies for enzyme/prodrug cancer therapy
G Xu, HL McLeod - Clinical Cancer Research, 2001 - AACR
The selective activation of prodrug (s) in tumor tissues by exogenous enzyme (s) for cancer
therapy can be accomplished by several ways, including gene-directed enzyme prodrug …
therapy can be accomplished by several ways, including gene-directed enzyme prodrug …
Engineering strategies to enhance TCR-based adoptive T cell therapy
JA Rath, C Arber - Cells, 2020 - mdpi.com
T cell receptor (TCR)-based adoptive T cell therapies (ACT) hold great promise for the
treatment of cancer, as TCRs can cover a broad range of target antigens. Here we …
treatment of cancer, as TCRs can cover a broad range of target antigens. Here we …
[HTML][HTML] Development of allogeneic HSC-engineered iNKT cells for off-the-shelf cancer immunotherapy
Cell-based immunotherapy has become the new-generation cancer medicine, and" off-the-
shelf" cell products that can be manufactured at large scale and distributed readily to treat …
shelf" cell products that can be manufactured at large scale and distributed readily to treat …
Infusion of suicide-gene-engineered donor lymphocytes after family haploidentical haemopoietic stem-cell transplantation for leukaemia (the TK007 trial): a non …
Background Procedures to prevent severe graft-versus-host disease (GVHD) delay immune
reconstitution secondary to transplants of haploidentical haemopoietic stem cells for the …
reconstitution secondary to transplants of haploidentical haemopoietic stem cells for the …
Analysis of transgene-specific immune responses that limit the in vivo persistence of adoptively transferred HSV-TK–modified donor T cells after allogeneic …
C Berger, ME Flowers, EH Warren, SR Riddell - Blood, 2006 - ashpublications.org
The introduction of an inducible suicide gene such as the herpes simplex virus thymidine
kinase (HSV-TK) might allow exploitation of the antitumor activity of donor T cells after …
kinase (HSV-TK) might allow exploitation of the antitumor activity of donor T cells after …
Administration of herpes simplex–thymidine kinase–expressing donor T cells with a T-cell–depleted allogeneic marrow graft
P Tiberghien, C Ferrand, B Lioure… - Blood, The Journal …, 2001 - ashpublications.org
Administration of donor T cells expressing the herpes simplex–thymidine kinase (HS-tk) with
a hematopoietic stem cell (HSC) transplantation could allow, if graft-versus-host disease …
a hematopoietic stem cell (HSC) transplantation could allow, if graft-versus-host disease …
[HTML][HTML] Inducible caspase 9 suicide gene to improve the safety of allodepleted T cells after haploidentical stem cell transplantation
Addback of donor T cells following T cell-depleted stem cell transplantation (SCT) can
accelerate immune reconstitution and be effective against relapsed malignancy. After …
accelerate immune reconstitution and be effective against relapsed malignancy. After …
The potential immunogenicity of the TK suicide gene does not prevent full clinical benefit associated with the use of TK-transduced donor lymphocytes in HSCT for …
C Traversari, S Marktel, Z Magnani… - Blood, The Journal …, 2007 - ashpublications.org
Gene therapy is a promising therapeutic strategy for genetic and acquired hematologic
diseases. With the improvements in gene transfer and expression, factors affecting safety …
diseases. With the improvements in gene transfer and expression, factors affecting safety …
Role of donor lymphocyte infusions in relapsed hematological malignancies after stem cell transplantation revisited
BACKGROUND: Treatment of relapsed hematological malignancies after an allogeneic
peripheral blood stem cell transplant (SCT) is challenging. Donor lymphocyte infusion (DLI) …
peripheral blood stem cell transplant (SCT) is challenging. Donor lymphocyte infusion (DLI) …
Serial in vivo imaging of the targeted migration of human HSV-TK-transduced antigen-specific lymphocytes
G Koehne, M Doubrovin, E Doubrovina… - Nature …, 2003 - nature.com
New technologies are needed to characterize the migration, survival, and function of antigen-
specific T cells in vivo. Here, we demonstrate that Epstein-Barr virus (EBV)–specific T cells …
specific T cells in vivo. Here, we demonstrate that Epstein-Barr virus (EBV)–specific T cells …