Abstract 30 years after the identification of WNTs, their signal transduction has become
increasingly complex, with the discovery of more than 15 receptors and co-receptors in …

In addition to activating β-catenin/TCF transcriptional complexes, Wnt proteins can elicit a
variety of other responses. These are often lumped together under the denominator …

LGR5+ stem cells reside at crypt bottoms, intermingled with Paneth cells that provide Wnt,
Notch and epidermal growth factor signals. Here we find that the related RNF43 and ZNRF3 …

About half of all melanomas harbor a mutation that results in a constitutively active BRAF
kinase mutant (BRAFV600E/K) that can be selectively inhibited by targeted BRAF inhibitors …

Receptor tyrosine kinases of the Ryk and Ror families were initially classified as orphan
receptors because their ligands were unknown. They are now known to contain functional …

Autophagy maintains cellular health and homeostasis during stress by delivering cytosolic
material captured by autophagosomes to lysosomes for degradation. Autophagosome …

To elucidate the role of centriolar satellites in ciliogenesis, we deleted the gene encoding
the PCM1 protein, an integral component of satellites. PCM1 null human cells show marked …

Wnt signaling pathways play important roles in tumorigenesis and are initiated by binding of
Wnt to various receptors including frizzleds (FZDs). FZDs are one of several families of …

Dysregulation of Notch signaling has been implicated in cellular transformation and
tumorigenesis in a variety of cancers while potential roles of MIB1, an E3 ubiquitin ligase …

miRNAs are small RNAs directing many developmental processes by posttranscriptional
regulation of protein-coding genes. We uncovered a new role for miR-1-1/133a-2 and miR-1 …