Sperm carries male genetic information, and flagella help move the sperm to reach oocytes.
When the ultrastructure of the flagella is abnormal, the sperm is unable to reach the oocyte …

Intraflagellar transport (IFT) trains are massive molecular machines that traffic proteins
between cilia and the cell body. Each IFT train is a dynamic polymer of two large complexes …

Intraflagellar transport (IFT) is the highly conserved process by which proteins are
transported along ciliary microtubules by a train-like polymeric assembly of IFT-A and IFT-B …

Intraflagellar transport (IFT) trains, the polymers composed of two multi-subunit complexes,
IFT-A and IFT-B, carry out bidirectional intracellular transport in cilia, vital for cilia biogenesis …

Cilia are tiny organelles with conserved structures and components in eukaryotic cells.
Ciliopathy is a set of diseases resulting from cilium dysfunction classified into first-order and …

The dynein-2 complex must be transported anterogradely within cilia to then drive
retrograde trafficking of the intraflagellar transport (IFT) machinery containing IFT-A and IFT …

ABSTRACT INPP5E, a phosphoinositide 5-phosphatase, localizes on the ciliary membrane
via its C-terminal prenyl moiety, and maintains the distinct ciliary phosphoinositide …

Primary cilia are antenna-like organelles that contain specific proteins, and are crucial for
tissue morphogenesis. Anterograde and retrograde trafficking of ciliary proteins are …

Owing to their crucial roles in development and homeostasis, defects in cilia cause
ciliopathies with diverse clinical manifestations. The intraflagellar transport (IFT) machinery …

The intraflagellar transport (IFT) machinery mediates the import and export of ciliary proteins
across the ciliary gate, as well as bidirectional protein trafficking within cilia. In addition to …