Signaling pathways in obesity: mechanisms and therapeutic interventions

X Wen, B Zhang, B Wu, H Xiao, Z Li, R Li… - Signal transduction and …, 2022 - nature.com
Obesity is a complex, chronic disease and global public health challenge. Characterized by
excessive fat accumulation in the body, obesity sharply increases the risk of several …

Progress and challenges in anti-obesity pharmacotherapy

DH Bessesen, LF Van Gaal - The lancet Diabetes & endocrinology, 2018 - thelancet.com
Obesity is a serious and growing worldwide health challenge. Healthy lifestyle choices are
the foundation of obesity treatment. However, weight loss can lead to physiological …

Pharmacological management of obesity: an endocrine Society clinical practice guideline

CM Apovian, LJ Aronne, DH Bessesen… - The Journal of …, 2015 - academic.oup.com
Objective: To formulate clinical practice guidelines for the pharmacological management of
obesity. Participants: An Endocrine Society-appointed Task Force of experts, a …

[HTML][HTML] Comprehensive review of current and upcoming anti-obesity drugs

JW Son, S Kim - Diabetes & metabolism journal, 2020 - synapse.koreamed.org
Obesity is among the leading causes of morbidity and mortality worldwide and its
prevalence continues to increase globally. Because obesity is a chronic, complex, and …

Advances in the Science, Treatment, and Prevention of the Disease of Obesity: Reflections From a Diabetes Care Editors' Expert Forum

WT Cefalu, GA Bray, PD Home, WT Garvey… - Diabetes …, 2015 - Am Diabetes Assoc
As obesity rates increase, so too do the risks of type 2 diabetes, cardiovascular disease, and
numerous other detrimental conditions. The prevalence of obesity in US adults more than …

Convertible visceral fat as a therapeutic target to curb obesity

A Giordano, A Frontini, S Cinti - Nature Reviews Drug Discovery, 2016 - nature.com
New therapeutic and preventative strategies are needed to address the growing obesity
epidemic. In animal models, brown adipose tissue activation and the associated heat …

Natural products with anti-obesity effects and different mechanisms of action

C Fu, Y Jiang, J Guo, Z Su - Journal of agricultural and food …, 2016 - ACS Publications
Obesity, a primary influence on health condition, causes numerous comorbidities and
complications and, therefore, pharmacotherapy is considered a strategy for its treatment …

Obesity management in Prader–Willi syndrome: Current perspectives

A Crinò, D Fintini, S Bocchini… - … , metabolic syndrome and …, 2018 - Taylor & Francis
Prader–Willi syndrome (PWS) is a complex multisystem disorder due to the absent
expression of the paternally active genes in the PWS critical region on chromosome 15 …

Evolution of pharmacological obesity treatments: focus on adverse side‐effect profiles

AJ Krentz, K Fujioka… - Diabetes, Obesity and …, 2016 - Wiley Online Library
Pharmacotherapy directed toward reducing body weight may provide benefits for both
curbing obesity and lowering the risk of obesity‐associated comorbidities; however, many …

The effect of healthy lifestyle strategies on the management of insulin resistance in children and adolescents with obesity: a narrative review

V Calcaterra, E Verduci, M Vandoni, V Rossi, G Fiore… - Nutrients, 2022 - mdpi.com
Childhood obesity is characterized by an increased risk of several metabolic derangements
including insulin resistance (IR). The strongest recommendations to prevent obesity and …