A characteristic feature of leukemia cells is a blockade of differentiation at a distinct stage in
cellular maturation. In the 1970s and 1980s, studies demonstrating the capabilities of certain …

BACKGROUND & AIMS: The peroxisome proliferator-activated receptor γ (PPARG,
PPARgamma) is a nuclear receptor that regulates expression of mediators of lipid …

Pancreatic adenocarcinoma remains an unresolved therapeutic challenge because of its
intrinsically refractoriness to both chemo-and radiotherapy due to the complexity of signaling …

The cancer preventive activity of vitamin E has been extensively discussed, but the activities
of specific forms of tocopherols have not received sufficient attention. Herein, we compared …

The importance of PPARγ (peroxisome proliferator‐activated receptor γ) in gastric cancer
(GC) is unclear. We investigated the role of PPARγ in GC cell lines and an animal model …

Aim: Linoleic acid (LA) and telmisartan as PPARgamma agonists exhibit anticancer activity.
The LA effect is observed for high non-achievable in vivo concentrations and in short …

The metabolic/cell signaling basis of Warburg's effect (“aerobic glycolysis”) and the general
metabolic phenotype adopted by cancer cells are first reviewed. Several bypasses are …

Peroxisome proliferator-activated receptor gamma (PPARγ), a member of the nuclear
receptor superfamily is an excellent example of targets that orchestrates cancer …

The emerging “anti-austerity” anti-cancer therapeutic strategy targets the ability of certain
cancer cell lines, particularly pancreatic cancer, to survive nutrient deprivation. While …

Pancreatic cancer stands as one of the most lethal malignancies, characterized by delayed
diagnosis, high mortality rates, limited treatment efficacy, and poor prognosis. Disulfidptosis …