Neurofibromatosis (NF) is a neurocutaneous syndrome characterized by the development of
tumors of the central or peripheral nervous system including the brain, spinal cord, organs …

Neurofibromatosis type 1 is a complex autosomal dominant disorder caused by germline
mutations in the NF1 tumour suppressor gene. Nearly all individuals with neurofibromatosis …

Despite a deeper molecular understanding, human glioblastoma remains one of the most
treatment refractory and fatal cancers. It is known that the presence of macrophages and …

Chimeric antigen receptor (CAR) T cells mediate potent antigen-specific antitumor activity;
however, their indirect effects on the endogenous immune system are not well …

We have extended our understanding of the molecular biology that underlies adult
glioblastoma over many years. By contrast, high-grade gliomas in children and adolescents …

Glioblastoma (GBM) is an incurable brain tumor with a median survival of approximately 15
months despite an aggressive standard of care that includes surgery, chemotherapy, and …

Animal experiments remain essential to understand the fundamental mechanisms
underpinning malignancy and to discover improved methods to prevent, diagnose and treat …

Human cancer cells typically harbour multiple chromosomal aberrations, nucleotide
substitutions and epigenetic modifications that drive malignant transformation. The Cancer …

To understand the relationships between the non-GCIMP glioblastoma (GBM) subgroups,
we performed mathematical modeling to predict the temporal sequence of driver events …

Glioblastoma multiforme (GBM) is the most common and aggressive malignant primary brain
tumor in humans. Here we show that gliomas can originate from differentiated cells in the …