Biological aging in childhood and adolescence following experiences of threat and deprivation: A systematic review and meta-analysis.
Life history theory argues that exposure to early life adversity (ELA) accelerates
development, although existing evidence for this varies. We present a meta-analysis and …
development, although existing evidence for this varies. We present a meta-analysis and …
Psychological and biological mechanisms linking trauma with cardiovascular disease risk
Cardiovascular disease (CVD) is the leading cause of death and disability worldwide, and
experiences of psychological trauma have been associated with subsequent CVD onset …
experiences of psychological trauma have been associated with subsequent CVD onset …
Mechanisms linking childhood trauma exposure and psychopathology: A transdiagnostic model of risk and resilience
Background Transdiagnostic processes confer risk for multiple types of psychopathology
and explain the co-occurrence of different disorders. For this reason, transdiagnostic …
and explain the co-occurrence of different disorders. For this reason, transdiagnostic …
Early experiences of threat, but not deprivation, are associated with accelerated biological aging in children and adolescents
Background Recent conceptual models argue that early life adversity (ELA) accelerates
development, which may contribute to poor mental and physical health outcomes. Evidence …
development, which may contribute to poor mental and physical health outcomes. Evidence …
Adversity exposure during sensitive periods predicts accelerated epigenetic aging in children
Objectives Exposure to adversity has been linked to accelerated biological aging, which in
turn has been shown to predict numerous physical and mental health problems. In recent …
turn has been shown to predict numerous physical and mental health problems. In recent …
The fetal programming of telomere biology hypothesis: an update
S Entringer, K de Punder, C Buss… - … Transactions of the …, 2018 - royalsocietypublishing.org
Research on mechanisms underlying fetal programming of health and disease risk has
focused primarily on processes that are specific to cell types, organs or phenotypes of …
focused primarily on processes that are specific to cell types, organs or phenotypes of …
Translating basic research knowledge on the biological embedding of early-life stress into novel approaches for the developmental programming of lifelong health
This review integrates scientific knowledge obtained over the past few decades on the
biological mechanisms that contribute to the profound association between exposure to …
biological mechanisms that contribute to the profound association between exposure to …
Stress, telomeres, and psychopathology: toward a deeper understanding of a triad of early aging
ES Epel, AA Prather - Annual review of clinical psychology, 2018 - annualreviews.org
Telomeres play an important part in aging and show relationships to lifetime adversity,
particularly childhood adversity. Meta-analyses demonstrate reliable associations between …
particularly childhood adversity. Meta-analyses demonstrate reliable associations between …
Childhood obesity within the lens of racism
Despite decades of research and a multitude of prevention and treatment efforts, childhood
obesity in the United States continues to affect nearly 1 in 5 (19.3%) children, with …
obesity in the United States continues to affect nearly 1 in 5 (19.3%) children, with …
Stress and immunosenescence: The role of telomerase
K de Punder, C Heim, PD Wadhwa… - Psychoneuroendocrinology, 2019 - Elsevier
Chronic stress is associated with the accelerated aging of the immune system and
represents a potent risk factor for the development and progression of a wide range of …
represents a potent risk factor for the development and progression of a wide range of …