Transition state asymmetry in C–H bond cleavage by proton-coupled electron transfer

JW Darcy, SS Kolmar, JM Mayer - Journal of the American …, 2019 - ACS Publications
The selective transformation of C–H bonds is a longstanding challenge in modern chemistry.
A recent report details C–H oxidation via multiple-site concerted proton–electron transfer …

Isolating the effects of the proton tunneling distance on proton-coupled electron transfer in a series of homologous tyrosine-base model compounds

SD Glover, GA Parada, TF Markle, S Ott… - Journal of the …, 2017 - ACS Publications
The distance dependence of concerted proton-coupled electron transfer (PCET) reactions
was probed in a series of three new compounds, where a phenol is covalently bridged by a …

When a Twist Makes a Difference: Exploring PCET and ESIPT on a Nonplanar Hydrogen-Bonded Donor–Acceptor System

E Odella, JH Fetherolf, M Secor, L DiPaola… - The Journal of …, 2024 - ACS Publications
Bioinspired benzimidazole-phenol constructs with an intramolecular hydrogen bond
connecting the phenol and the benzimidazole have been synthesized to study both proton …

Exploring the structure-activity relationship of benzylidene-2, 3-dihydro-1H-inden-1-one compared to benzofuran-3 (2H)-one derivatives as inhibitors of tau amyloid …

E Boukherrouba, C Larosa, KA Nguyen… - European Journal of …, 2022 - Elsevier
Tauopathies, such as Alzheimer's disease, have been the subject of several hypotheses
regarding the way to treat them. Hyperphosphorylation of tau protein leading to its …

Two‐Step Access to β‐Substituted o‐Hydroxyphenyl Ethyl Ketones from 4‐Chromanone and its Application in Preparation of a Silica‐Supported Cobalt(II) Salen …

L Guo, M Ye, L Vaccaro, M Li… - Advanced Synthesis & …, 2021 - Wiley Online Library
The o‐hydroxyphenyl ethyl ketone skeleton is prevalent in many biologically active natural
products and active pharmaceutical ingredients. Herein, a two‐step protocol has been …

[PDF][PDF] Developing A New Class of Molecular Machine: Light‐Fuelled Single‐Bond Rotors

OM Bayley - 2023 - research-information.bris.ac.uk
Due to the central role of molecular machines in biological systems, chemists have long
sought to create synthetic equivalents, for the development of future nanoscale …

Multiple-Site Concerted Proton-Electron Transfer in Small Molecule Systems and Extensions to PCET at Carbon

JW Darcy - 2019 - search.proquest.com
Proton-coupled electron transfer (PCET) describes reactions involving the transfer (s) of
electrons (e–) and protons (H+). Hydrogen atom transfer (HAT), one of the most widely …