Molecular characteristics, immune evasion, and impact of SARS-CoV-2 variants
The persistent COVID-19 pandemic since 2020 has brought an enormous public health
burden to the global society and is accompanied by various evolution of the virus genome …
burden to the global society and is accompanied by various evolution of the virus genome …
Small molecules in the treatment of COVID-19
S Lei, X Chen, J Wu, X Duan, K Men - Signal transduction and targeted …, 2022 - nature.com
The outbreak of COVID-19 has become a global crisis, and brought severe disruptions to
societies and economies. Until now, effective therapeutics against COVID-19 are in high …
societies and economies. Until now, effective therapeutics against COVID-19 are in high …
Synthesis and characterization of gelatin/lignin hydrogels as quick release drug carriers for Ribavirin
In this study, hydrogels based on gelatin and lignin were fabricated as efficient drug carriers
for Ribavirin. The obtained hydrogels were characterized by scanning electron microscopy …
for Ribavirin. The obtained hydrogels were characterized by scanning electron microscopy …
Targeting SARS-CoV-2 proteases for COVID-19 antiviral development
The emergence of severe acute respiratory syndrome (SARS-CoV-2) in 2019 marked the
third occurrence of a highly pathogenic coronavirus in the human population since 2003. As …
third occurrence of a highly pathogenic coronavirus in the human population since 2003. As …
Drug combinations as a first line of defense against coronaviruses and other emerging viruses
The world was unprepared for coronavirus disease 2019 (COVID-19) and remains ill-
equipped for future pandemics. While unprecedented strides have been made developing …
equipped for future pandemics. While unprecedented strides have been made developing …
Flavonoids in Ampelopsis grossedentata as covalent inhibitors of SARS-CoV-2 3CLpro: Inhibition potentials, covalent binding sites and inhibitory mechanisms
Y Xiong, GH Zhu, YN Zhang, Q Hu, HN Wang… - International Journal of …, 2021 - Elsevier
Abstract Coronavirus 3C-like protease (3CL pro) is a crucial target for treating coronavirus
diseases including COVID-19. Our preliminary screening showed that Ampelopsis …
diseases including COVID-19. Our preliminary screening showed that Ampelopsis …
[HTML][HTML] Efficacy and safety of SIM0417 (SSD8432) plus ritonavir for COVID-19 treatment: a randomised, double-blind, placebo-controlled, phase 1b trial
F Wang, W Xiao, Y Tang, M Cao, D Shu… - The Lancet Regional …, 2023 - thelancet.com
Summary Background SIM0417 (SSD8432) is an orally administered coronavirus main
proteinase (3CL pro) inhibitor with potential anti-SARS-CoV-2 activity. This study aimed to …
proteinase (3CL pro) inhibitor with potential anti-SARS-CoV-2 activity. This study aimed to …
Potential inhibitors targeting papain-like protease of SARS-CoV-2: two birds with one stone
H Jiang, P Yang, J Zhang - Frontiers in chemistry, 2022 - frontiersin.org
Severe acute respiratory syndrome Coronavirus-2 (SARS-CoV-2), the pathogen of the
Coronavirus disease-19 (COVID-19), is still devastating the world causing significant chaos …
Coronavirus disease-19 (COVID-19), is still devastating the world causing significant chaos …
AI-accelerated protein-ligand docking for SARS-CoV-2 is 100-fold faster with no significant change in detection
Protein-ligand docking is a computational method for identifying drug leads. The method is
capable of narrowing a vast library of compounds down to a tractable size for downstream …
capable of narrowing a vast library of compounds down to a tractable size for downstream …
Beyond the vaccines: a glance at the small molecule and peptide-based anti-COVID19 arsenal
Unprecedented efforts of the researchers have been witnessed in the recent past towards
the development of vaccine platforms for the control of the COVID-19 pandemic. Albeit …
the development of vaccine platforms for the control of the COVID-19 pandemic. Albeit …