B cells in autoimmune and neurodegenerative central nervous system diseases
B cells are essential components of the adaptive immune system and have important roles
in the pathogenesis of several central nervous system (CNS) diseases. Besides producing …
in the pathogenesis of several central nervous system (CNS) diseases. Besides producing …
B and T cells driving multiple sclerosis: identity, mechanisms and potential triggers
J Van Langelaar, L Rijvers, J Smolders… - Frontiers in …, 2020 - frontiersin.org
Historically, multiple sclerosis (MS) has been viewed as being primarily driven by T cells.
However, the effective use of anti-CD20 treatment now also reveals an important role for B …
However, the effective use of anti-CD20 treatment now also reveals an important role for B …
Memory B cells are major targets for effective immunotherapy in relapsing multiple sclerosis
Although multiple sclerosis (MS) is considered to be a CD4, Th17-mediated autoimmune
disease, supportive evidence is perhaps circumstantial, often based on animal studies, and …
disease, supportive evidence is perhaps circumstantial, often based on animal studies, and …
Immunological aspects of approved MS therapeutics
Multiple sclerosis (MS) is the most common neurological immune-mediated disease leading
to disability in young adults. The outcome of the disease is unpredictable, and over time …
to disability in young adults. The outcome of the disease is unpredictable, and over time …
Pre-clinical and clinical implications of “inside-out” vs.“outside-in” paradigms in multiple sclerosis etiopathogenesis
HE Titus, Y Chen, JR Podojil, AP Robinson… - Frontiers in cellular …, 2020 - frontiersin.org
Multiple Sclerosis (MS) is an immune-mediated neurological disorder, characterized by
central nervous system (CNS) inflammation, oligodendrocyte loss, demyelination, and …
central nervous system (CNS) inflammation, oligodendrocyte loss, demyelination, and …
The role of B cells and antibodies in multiple sclerosis, neuromyelitis optica, and related disorders
S Häusser-Kinzel, MS Weber - Frontiers in immunology, 2019 - frontiersin.org
Our pathophysiological concept of the most common central nervous system demyelinating
disease, multiple sclerosis, strikingly evolved by recent discoveries suggesting that B …
disease, multiple sclerosis, strikingly evolved by recent discoveries suggesting that B …
B cells in the multiple sclerosis central nervous system: trafficking and contribution to CNS-compartmentalized inflammation
Clinical trial results of peripheral B cell depletion indicate abnormal proinflammatory B cell
properties, and particularly antibody-independent functions, contribute to relapsing MS …
properties, and particularly antibody-independent functions, contribute to relapsing MS …
Immunoglobulin class-switched B cells form an active immune axis between CNS and periphery in multiple sclerosis
In multiple sclerosis (MS), lymphocyte—in particular B cell—transit between the central
nervous system (CNS) and periphery may contribute to the maintenance of active disease …
nervous system (CNS) and periphery may contribute to the maintenance of active disease …
B cell exchange across the blood-brain barrier in multiple sclerosis
In multiple sclerosis (MS) pathogenic B cells likely act on both sides of the blood-brain
barrier (BBB). However, it is unclear whether antigen-experienced B cells are shared …
barrier (BBB). However, it is unclear whether antigen-experienced B cells are shared …
Leaky brain in neurological and psychiatric disorders: Drivers and consequences
G Morris, BS Fernandes, BK Puri… - Australian & New …, 2018 - journals.sagepub.com
Background: The blood–brain barrier acts as a highly regulated interface; its dysfunction
may exacerbate, and perhaps initiate, neurological and neuropsychiatric disorders …
may exacerbate, and perhaps initiate, neurological and neuropsychiatric disorders …