Concise review: mesenchymal stem (stromal) cells: biology and preclinical evidence for therapeutic potential for organ dysfunction following trauma or sepsis

MA Matthay, S Pati, JW Lee - Stem Cells, 2017 - academic.oup.com
Several experimental studies have provided evidence that bone-marrow derived
mesenchymal stem (stromal) cells (MSC) may be effective in treating critically ill surgical …

[HTML][HTML] Pneumonia, acute respiratory distress syndrome, and early immune-modulator therapy

KY Lee - International Journal of Molecular Sciences, 2017 - mdpi.com
Acute respiratory distress syndrome (ARDS) is caused by infectious insults, such as
pneumonia from various pathogens or related to other noninfectious events. Clinical and …

[HTML][HTML] Prevalence and outcome of acute respiratory distress syndrome in traumatic brain injury: a systematic review and meta-analysis

TH Fan, M Huang, A Gedansky, C Price, C Robba… - Lung, 2021 - Springer
Objectives Acute respiratory distress syndrome (ARDS) in patients with traumatic brain injury
(TBI) is associated with increased mortality. Information on the prevalence of ARDS and its …

Traumatic brain injury-induced acute lung injury: evidence for activation and inhibition of a neural-respiratory-inflammasome axis

NA Kerr, JP de Rivero Vaccari, S Abbassi… - Journal of …, 2018 - liebertpub.com
Abstract Approximately 20–25% of traumatic brain injury (TBI) subjects develop acute lung
injury (ALI), but the pathomechanisms of TBI-induced ALI remain poorly defined. Our …

[HTML][HTML] 17α-Ethinyl estradiol-3-sulfate increases survival and hemodynamic functioning in a large animal model of combined traumatic brain injury and hemorrhagic …

AR Mayer, AB Dodd, JG Rannou-Latella… - Critical Care, 2021 - Springer
Background Traumatic brain injury (TBI) and severe blood loss resulting in hemorrhagic
shock (HS) represent leading causes of trauma-induced mortality, especially when co …

Acute brain trauma, lung injury, and pneumonia: more than just altered mental status and decreased airway protection

PJ Hu, JF Pittet, JD Kerby… - American Journal of …, 2017 - journals.physiology.org
Traumatic brain injury (TBI) is a major cause of mortality and morbidity worldwide. Even
when patients survive the initial insult, there is significant morbidity and mortality secondary …

[HTML][HTML] Human lung cell pyroptosis following traumatic brain injury

NA Kerr, JP de Rivero Vaccari, O Umland, MR Bullock… - Cells, 2019 - mdpi.com
Approximately 30% of traumatic brain injured patients suffer from acute lung injury or acute
respiratory distress syndrome. Our previous work revealed that extracellular vesicle (EV) …

Neural-respiratory inflammasome axis in traumatic brain injury

N Kerr, JP de Rivero Vaccari, WD Dietrich… - Experimental …, 2020 - Elsevier
Traumatic brain injury (TBI) is a leading cause of morbidity and mortality. Approximately 20–
25% of TBI subjects develop Acute Lung Injury (ALI), but the pathomechanisms of TBI …

Amicus or adversary revisited: platelets in acute lung injury and acute respiratory distress syndrome

EA Middleton, MT Rondina, H Schwertz… - American journal of …, 2018 - atsjournals.org
Platelets are essential cellular effectors of hemostasis and contribute to disease as
circulating effectors of pathologic thrombosis. These are their most widely known biologic …

Prognostic factors for development of acute respiratory distress syndrome following traumatic injury: a systematic review and meta-analysis

A Tran, SM Fernando, LJ Brochard… - European …, 2022 - Eur Respiratory Soc
Background Our purpose was to summarise the prognostic associations between various
clinical risk factors and development of acute respiratory distress syndrome (ARDS) …