Boronic acids and their derivatives in medicinal chemistry: synthesis and biological applications

MP Silva, L Saraiva, M Pinto, ME Sousa - Molecules, 2020 - mdpi.com
Boron containing compounds have not been widely studied in Medicinal Chemistry, mainly
due to the idea that this group could confer some toxicity. Nowadays, this concept has been …

Promising Schiff bases in antiviral drug design and discovery

S Kaushik, SK Paliwal, MR Iyer, VM Patil - Medicinal Chemistry Research, 2023 - Springer
Emerging and re-emerging illnesses will probably present a new hazard of infectious
diseases and have fostered the urge to research new antiviral agents. Most of the antiviral …

Could respiratory fluoroquinolones, levofloxacin and moxifloxacin, prove to be beneficial as an adjunct treatment in COVID-19?

I Karampela, M Dalamaga - Archives of medical research, 2020 - Elsevier
Since the beginning of the COVID-19 pandemic, researchers have focused on repurposing
of existing antibiotics, antivirals and anti-inflammatory drugs to find an effective therapy …

Inadequate use of antibiotics in the covid-19 era: effectiveness of antibiotic therapy

AD Bendala Estrada, J Calderón Parra… - BMC infectious …, 2021 - Springer
Abstract Background Since December 2019, the COVID-19 pandemic has changed the
concept of medicine. This work aims to analyze the use of antibiotics in patients admitted to …

Repurposing of antibiotics for clinical management of COVID-19: a narrative review

A Yacouba, A Olowo-Okere, I Yunusa - Annals of Clinical Microbiology …, 2021 - Springer
Background Drug repurposing otherwise known as drug repositioning or drug re-profiling is
a time-tested approach in drug discovery through which new medical uses are being …

Ciprofloxacin and moxifloxacin could interact with SARS-CoV-2 protease: preliminary in silico analysis

K Marciniec, A Beberok, P Pęcak, S Boryczka… - Pharmacological …, 2020 - Springer
Background A large body of research has focused on fluoroquinolones. It was shown that
this class of synthetic antibiotics could possess antiviral activity as a broad range of anti …

Nonclassical biological activities of quinolone derivatives

M Daneshtalab, A Ahmed - Journal of Pharmacy & …, 2012 - journals.library.ualberta.ca
Quinolones are considered as a big family of multi-faceted drugs; their chemical synthesis is
flexible and can be easily adapted to prepare new congeners with rationally devised …

In vitro inhibition and molecular docking of a new ciprofloxacin‐chalcone against SARS‐CoV‐2 main protease

R Alaaeldin, M Mustafa… - Fundamental & …, 2022 - Wiley Online Library
Abstract Background/Aim SARS‐CoV‐2 is one of the coronavirus families that emerged at
the end of 2019. It infected the respiratory system and caused a pandemic worldwide …

Antivirals of ethnomedicinal origin: structure-activity relationship and scope

D Chattopadhyay, TN Naik - Mini reviews in medicinal …, 2007 - ingentaconnect.com
Ethnomedicinal plants have been used as source of candidate drugs for almost all diseases,
but the number of compounds having antiviral activity is scarce. Irrespective of type of …

Inhibition of hepatitis C virus replication by chalepin and pseudane IX isolated from Ruta angustifolia leaves

TS Wahyuni, A Widyawaruyanti, MI Lusida, A Fuad… - Fitoterapia, 2014 - Elsevier
Hepatitis C virus (HCV) infection is highly prevalent among global populations, with an
estimated number of infected patients being 170 million. Approximately 70–80% of patients …