Therapeutic approaches for cardiac regeneration and repair

H Hashimoto, EN Olson, R Bassel-Duby - Nature Reviews Cardiology, 2018 - nature.com
Ischaemic heart disease is a leading cause of death worldwide. Injury to the heart is
followed by loss of the damaged cardiomyocytes, which are replaced with fibrotic scar …

Stem cell therapy in heart diseases–cell types, mechanisms and improvement strategies

P Müller, H Lemcke, R David - Cellular Physiology and Biochemistry, 2018 - karger.com
A large number of clinical trials have shown stem cell therapy to be a promising therapeutic
approach for the treatment of cardiovascular diseases. Since the first transplantation into …

An acute immune response underlies the benefit of cardiac stem cell therapy

RJ Vagnozzi, M Maillet, MA Sargent, H Khalil… - Nature, 2020 - nature.com
Clinical trials using adult stem cells to regenerate damaged heart tissue continue to this
day,, despite ongoing questions of efficacy and a lack of mechanistic understanding of the …

[HTML][HTML] Dynamics of cell generation and turnover in the human heart

O Bergmann, S Zdunek, A Felker, M Salehpour… - Cell, 2015 - cell.com
The contribution of cell generation to physiological heart growth and maintenance in
humans has been difficult to establish and has remained controversial. We report that the full …

Aged‐senescent cells contribute to impaired heart regeneration

FC Lewis‐McDougall, PJ Ruchaya… - Aging cell, 2019 - Wiley Online Library
Aging leads to increased cellular senescence and is associated with decreased potency of
tissue‐specific stem/progenitor cells. Here, we have done an extensive analysis of cardiac …

Heart regeneration and repair after myocardial infarction: translational opportunities for novel therapeutics

TJ Cahill, RP Choudhury, PR Riley - Nature Reviews Drug Discovery, 2017 - nature.com
Current therapies for heart failure after myocardial infarction are limited and non-curative.
Although regenerative approaches are receiving significant attention, clinical efforts that …

Novel therapeutic strategies targeting fibroblasts and fibrosis in heart disease

RG Gourdie, S Dimmeler, P Kohl - Nature reviews Drug discovery, 2016 - nature.com
Our understanding of the functions of cardiac fibroblasts has moved beyond their roles in
heart structure and extracellular matrix generation and now includes their contributions to …

c-kit+ cells minimally contribute cardiomyocytes to the heart

JH Van Berlo, O Kanisicak, M Maillet, RJ Vagnozzi… - Nature, 2014 - nature.com
If and how the heart regenerates after an injury event is highly debated. c-kit-expressing
cardiac progenitor cells have been reported as the primary source for generation of new …

Heart regeneration by endogenous stem cells and cardiomyocyte proliferation: controversy, fallacy, and progress

L He, NB Nguyen, R Ardehali, B Zhou - Circulation, 2020 - Am Heart Assoc
Ischemic heart disease is the leading cause of death worldwide. Myocardial infarction
results in an irreversible loss of cardiomyocytes with subsequent adverse remodeling and …

Resident c-kit+ cells in the heart are not cardiac stem cells

N Sultana, L Zhang, J Yan, J Chen, W Cai… - Nature …, 2015 - nature.com
Identifying a bona fide population of cardiac stem cells (CSCs) is a critical step for
developing cell-based therapies for heart failure patients. Previously, cardiac c-kit+ cells …