Acute pancreatitis: diagnosis and treatment

P Szatmary, T Grammatikopoulos, W Cai, W Huang… - Drugs, 2022 - Springer
Acute pancreatitis is a common indication for hospital admission, increasing in incidence,
including in children, pregnancy and the elderly. Moderately severe acute pancreatitis with …

British Society of Gastroenterology consensus guidelines on the management of inflammatory bowel disease in adults

CA Lamb, NA Kennedy, T Raine, PA Hendy, PJ Smith… - Gut, 2019 - gut.bmj.com
Ulcerative colitis and Crohn's disease are the principal forms of inflammatory bowel disease.
Both represent chronic inflammation of the gastrointestinal tract, which displays …

Approach to the management of recently diagnosed inflammatory bowel disease patients: a user's guide for adult and pediatric gastroenterologists

M Agrawal, EA Spencer, JF Colombel, RC Ungaro - Gastroenterology, 2021 - Elsevier
Inflammatory bowel diseases (IBDs), including Crohn's disease and ulcerative colitis, are
chronic, progressive, immune-mediated diseases of adults and children that have no cure …

Drug-induced liver injury: recent advances in diagnosis and risk assessment

GA Kullak-Ublick, RJ Andrade, M Merz, P End… - Gut, 2017 - gut.bmj.com
Idiosyncratic drug-induced liver injury (IDILI) is a rare but potentially severe adverse drug
reaction that should be considered in patients who develop laboratory criteria for liver injury …

Genetics of inflammatory bowel diseases

DPB McGovern, S Kugathasan, JH Cho - Gastroenterology, 2015 - Elsevier
In this review, we provide an update on genome-wide association studies (GWAS) in
inflammatory bowel disease (IBD). In addition, we summarize progress in defining the …

10 years of GWAS discovery: biology, function, and translation

PM Visscher, NR Wray, Q Zhang, P Sklar… - The American Journal of …, 2017 - cell.com
Application of the experimental design of genome-wide association studies (GWASs) is now
10 years old (young), and here we review the remarkable range of discoveries it has …

Clinical genomics for the diagnosis of monogenic forms of inflammatory bowel disease: a position paper from the Paediatric IBD Porto Group of European Society of …

HH Uhlig, F Charbit-Henrion, D Kotlarz… - Journal of pediatric …, 2021 - journals.lww.com
Background: It is important to identify patients with monogenic IBD as management may
differ from classical IBD. In this position statement we formulate recommendations for the …

Genetics and epigenetics of IBD

V Annese - Pharmacological research, 2020 - Elsevier
Inflammatory bowel diseases (IBD) are chronic intermittent inflammatory disorders of the
gastrointestinal tract of unknown etiology but a clear genetic predisposition. Prompted by the …

Association of genetic variants in NUDT15 with thiopurine-induced myelosuppression in patients with inflammatory bowel disease

GJ Walker, JW Harrison, GA Heap, MD Voskuil… - Jama, 2019 - jamanetwork.com
Importance Use of thiopurines may be limited by myelosuppression. TPMTpharmacogenetic
testing identifies only 25% of at-risk patients of European ancestry. Among patients of East …

Genetics of inflammatory bowel disease: beyond NOD2

MU Mirkov, B Verstockt, I Cleynen - The lancet Gastroenterology & …, 2017 - thelancet.com
The study of the genetic underpinnings of inflammatory bowel disease has made great
progress since the identification of NOD2 as a major susceptibility gene. Novel genotyping …