Stem cells are considered the fundamental underpinnings of tissue biology. The stem cell
microenvironment provides factors and elements that play significant roles in controlling the …

Gene editing to disrupt the GATA1-binding site at the+ 58 BCL11A erythroid enhancer could
induce γ-globin expression, which is a promising therapeutic strategy to alleviate β …

Mass cytometry, or Cytometry by Time-Of-Flight, is a powerful new platform for high-
dimensional single-cell analysis of the immune system. It enables the simultaneous …

Hematopoietic stem cells (HSCs) are multipotent progenitor cells that can differentiate and
replenish blood and immune cells. While there is a growing demand for autologous and …

Purpose To describe the nutritional status in patients undergoing hematopoietic stem cell
transplant (HSCT) in three different defined moments: at admission to the Bone Marrow …

Background and aims As a curative procedure, hematopoietic stemcell transplantation
(HSCT) is an approved treatment for many malignant orbenign hematologic and non …

Background Intravenous high-dose melphalan has a short half-life, and application of this
single drug in MM transplant favors the use of stem cells without cryopreservation, for wider …

Successful expansion of bone marrow (BM) hematopoietic stem and progenitor cells
(HSPCs) would benefit many HSPC transplantation and gene therapy/editing applications …

Recent studies demonstrated that myeloid-derived suppressor cells (MDSCs) are involved
in the pathogenesis and progression of multiple myeloma (MM). Nevertheless, data on the …

Objectives Autologous peripheral blood stem cells transplantation (APBSCT) is a
therapeutic option which can be used in various hematological, neoplastic disorders …